Examining muscle function in survivors of childhood leukemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between mitochondrial function and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). It aims to compare muscle mitochondrial oxidative phosphorylation (mtOXPHOS) activity and satellite cell content between ALL survivors and healthy controls. Participants will undergo non-invasive metabolic imaging using MRI and MRS, alongside physical function assessments and muscle biopsies. The study seeks to understand how cancer and its treatment may affect muscle health in these survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Survivor- or Control-Participant is age 18 years old or older at time of consent and enrolled in SJLIFE.
* Survivor- Participant is childhood ALL survivor
* Survivor- or Control Participant has low muscle mass as defined by relative lean mass z-score of less than or equal to -0.5 SD (lean mass divided by height in meters squared).
* Survivor - Participant is able and willing to give informed consent

Exclusion Criteria:

* Survivor-Participant has history of cranial radiation.
* Survivor- or Control-Participant has implanted medical devices or metal that would interfere with MRI or MRS
* Female Survivor- or Control-Participant is pregnant.
* Survivor- or Control-Participant is taking anticoagulants (e.g. aspirin, apixaban, coumadin, edoxaban, rivaroxaban)
* Survivor- or Control-Participant weighs more than 300 pounds.
* Survivor- or Control-Participant is allergic to local anesthetic (i.e., lidocaine, bupivacaine).
* Survivor- or Control-Participant cannot lie flat on his/her back for 90 minutes or longer
* Survivor- or Control-Participant has a current history of peripheral motor neuropathy.

Where it's running

• St. Jude Children's Research Hospital
  Memphis, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Puneet Bagga, PhD — St. Jude Children's Research Hospital
• Study coordinator: Puneet Bagga, PhD
• Email: referralinfo@stjude.org
• Phone: 888-226-4343

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.