Healthy Hearts: improving heart screening for adult childhood cancer survivors
Evaluation Of Cardiovascular Health Outcomes Among Survivors 2 (ECHOS2)
This trial tests an online Healthy Hearts program to help adult childhood cancer survivors at higher heart risk get the recommended echocardiogram screening.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 350 (estimated) |
| Ages | 26 Years and up |
| Sex | All |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Drugs / interventions | radiation, doxorubicin |
| Locations | 1 site (Memphis, Tennessee) |
| Trial ID | NCT07245420 on ClinicalTrials.gov |
What this trial studies
Participants who are adult members of the Childhood Cancer Survivor Study who meet treatment-based heart-risk criteria will complete a 15–20 minute baseline survey and then be randomly assigned to the Healthy Hearts eHealth intervention or to receive standard survivorship educational materials delivered via the CIAS platform. All participants receive a personalized survivorship care plan and educational materials, while the intervention arm also receives CIAS-delivered motivational interviewing components including an avatar script, video vignettes, and patient testimonials. The primary outcome is adherence to recommended screening echocardiogram within the follow-up window, with secondary outcomes measuring mediators of screening behavior. The trial is led by St. Jude Children’s Research Hospital and leverages online delivery to reach eligible CCSS participants.
Who should consider this trial
Good fit: Ideal candidates are adult (age ≥26) Childhood Cancer Survivor Study participants who received high-dose anthracycline or chest radiation, have no history of cardiomyopathy, have not had an echocardiogram in the past 5 years, are English-speaking, and have completed prior CCSS surveys.
Not a fit: Patients already enrolled in long-term follow-up programs that provide risk-based cardiac screening, those with a recent echocardiogram, or those with existing cardiomyopathy are unlikely to gain additional benefit from this intervention.
Why it matters
Potential benefit: If successful, the program could increase uptake of recommended echocardiogram screening and enable earlier detection of heart problems in high-risk childhood cancer survivors.
How similar studies have performed: Previous eHealth and motivational interviewing approaches have improved screening and health behaviors in other populations, but this specific Healthy Hearts intervention in high-risk childhood cancer survivors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Childhood Cancer Survivor Study (CCSS) Participants * Age ≥26 years * Treated with cumulative doxorubicin equivalent anthracycline doses ≥100 mg/m2 with any/no radiation, or ≥15 Gy chest radiation with any/no anthracyclines * No history of cardiomyopathy * Has not had an echocardiogram in the previous 5 years * Has a history of successful completion of CCSS surveys * English-Speaking * Has not been enrolled in ECHOS-1 (pilot) Exclusion Criteria: • Currently participating in a long-term follow-up program that provides risk-based screening
Where this trial is running
Memphis, Tennessee
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Matthew Ehrhardt, MD, MS, MPI — St. Jude Children's Research Hospital
- Study coordinator: Matthew Ehrhardt, MD, MS, MPI
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.