Healthy Hearts: improving heart screening for adult childhood cancer survivors
Official title: Evaluation Of Cardiovascular Health Outcomes Among Survivors 2 (ECHOS2)
Run by St. Jude Children's Research Hospital · NCT07245420 · Data updated 2026-11-12
This trial tests an online Healthy Hearts program to help adult childhood cancer survivors at higher heart risk get the recommended echocardiogram screening.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 26 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Drugs / interventions | radiation, doxorubicin |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | September 2026 |
| Main results expected | December 2029 |
| Study ends | December 2030 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT07245420 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult (age ≥26) Childhood Cancer Survivor Study participants who received high-dose anthracycline or chest radiation, have no history of cardiomyopathy, have not had an echocardiogram in the past 5 years, are English-speaking, and have completed prior CCSS surveys.
✕Probably not a fit
Patients already enrolled in long-term follow-up programs that provide risk-based cardiac screening, those with a recent echocardiogram, or those with existing cardiomyopathy are unlikely to gain additional benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants who are adult members of the Childhood Cancer Survivor Study who meet treatment-based heart-risk criteria will complete a 15–20 minute baseline survey and then be randomly assigned to the Healthy Hearts eHealth intervention or to receive standard survivorship educational materials delivered via the CIAS platform. All participants receive a personalized survivorship care plan and educational materials, while the intervention arm also receives CIAS-delivered motivational interviewing components including an avatar script, video vignettes, and patient testimonials. The primary outcome is adherence to recommended screening echocardiogram within the follow-up window, with secondary outcomes measuring mediators of screening behavior. The trial is led by St. Jude Children’s Research Hospital and leverages online delivery to reach eligible CCSS participants.
Why it matters
Potential benefit: If successful, the program could increase uptake of recommended echocardiogram screening and enable earlier detection of heart problems in high-risk childhood cancer survivors.
How similar studies have gone: Previous eHealth and motivational interviewing approaches have improved screening and health behaviors in other populations, but this specific Healthy Hearts intervention in high-risk childhood cancer survivors is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Childhood Cancer Survivor Study (CCSS) Participants * Age ≥26 years * Treated with cumulative doxorubicin equivalent anthracycline doses ≥100 mg/m2 with any/no radiation, or ≥15 Gy chest radiation with any/no anthracyclines * No history of cardiomyopathy * Has not had an echocardiogram in the previous 5 years * Has a history of successful completion of CCSS surveys * English-Speaking * Has not been enrolled in ECHOS-1 (pilot) Exclusion Criteria: • Currently participating in a long-term follow-up program that provides risk-based screening
Where it's running
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St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Matthew Ehrhardt, MD, MS, MPI — St. Jude Children's Research Hospital
- Study coordinator: Matthew Ehrhardt, MD, MS, MPI
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.