Long-term health effects of childhood cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Childhood Cancer Survivor Study investigates the long-term health outcomes of individuals diagnosed with cancer before the age of 21. This observational study will follow a cohort of approximately 50,000 cancer survivors and 10,000 sibling controls, focusing on the effects of various cancer treatments such as chemotherapy and radiation. Researchers will analyze health-related behaviors, medical care patterns, and the risk of late-occurring adverse health outcomes. Additionally, biological samples will be collected for future research to correlate with health outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Initial Cohort:

* Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

* Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
* English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.

Exclusion Criteria:

* Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
* Non-English speaking or residence outside the US or Canada.

Sibling Controls:

* For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.

Where it's running

• University of Alabama at Birmingham/Children's of Alabama
  Birmingham, Alabama, United States Recruiting
• City of Hope National Medical Center
  Duarte, California, United States Recruiting
• Children's Hospital Los Angeles
  Los Angeles, California, United States Recruiting
• University of California-Los Angeles
  Los Angeles, California, United States Recruiting
• Children's Hospital of Orange County
  Orange, California, United States Recruiting
• University of California-San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Gregory T. Armstrong, MD, MSCE — St. Jude Children's Research Hospital
• Study coordinator: Gregory T. Armstrong, MD, MSCE
• Email: referralinfo@stjude.org
• Phone: 888-226-4343

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.