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Long-term health effects of childhood cancer survivors

Childhood Cancer Survivor Study

Observational St. Jude Children's Research Hospital · NCT01120353

This study looks at the long-term health of people who survived cancer as kids to see how their treatments might affect their health later in life.

Quick facts

Study typeObservational
Enrollment50000 (estimated)
SexAll
SponsorSt. Jude Children's Research Hospital Academic / other
Drugs / interventionschemotherapy, radiation
Locations31 sites (Birmingham, Alabama and 30 other locations)
Trial IDNCT01120353 on ClinicalTrials.gov

What this trial studies

The Childhood Cancer Survivor Study investigates the long-term health outcomes of individuals diagnosed with cancer before the age of 21. This observational study will follow a cohort of approximately 50,000 cancer survivors and 10,000 sibling controls, focusing on the effects of various cancer treatments such as chemotherapy and radiation. Researchers will analyze health-related behaviors, medical care patterns, and the risk of late-occurring adverse health outcomes. Additionally, biological samples will be collected for future research to correlate with health outcomes.

Who should consider this trial

Good fit: Ideal candidates include individuals who survived specific types of cancer before age 21 and are English- or Spanish-speaking residents of the U.S. or Canada.

Not a fit: Patients diagnosed with non-malignant tumors or those who do not meet the language or residency criteria may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the long-term health needs of childhood cancer survivors, leading to improved care and monitoring strategies.

How similar studies have performed: Previous studies on childhood cancer survivors have shown significant findings regarding long-term health effects, indicating that this approach is supported by existing research.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

Initial Cohort:

* Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

* Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
* English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.

Exclusion Criteria:

* Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
* Non-English speaking or residence outside the US or Canada.

Sibling Controls:

* For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.

Where this trial is running

Birmingham, Alabama and 30 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions CancerChildhood cancerYoung ChildrenAdults
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.