Remote diagnosis of heart issues in childhood cancer survivors
Official title: Assessment of Remote Approaches for Identification of Autonomic Dysfunction Among Survivors of Leukemia and Lymphoma
Run by St. Jude Children's Research Hospital · NCT06747910 · Data updated 2026-11-12
This study is testing if a new wrist biosensor can help find heart problems in childhood cancer survivors more easily than regular check-ups.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 188 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | February 3, 2025 |
| Main results expected | December 2026 |
| Study ends | June 2027 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT06747910 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals over 18 years old who are survivors of acute lymphoblastic leukemia or Hodgkin's lymphoma and are not currently on beta-blocker medication.
✕Probably not a fit
Patients who cannot communicate in English, have acute heart failure, or are currently pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate whether cardiac autonomic dysfunction (AD) can be accurately diagnosed remotely using biosensor technology, compared to traditional in-person assessments. Participants, who are survivors of acute lymphoblastic leukemia and Hodgkin's lymphoma, will undergo a standardized clinical assessment known as the Ewing battery, followed by a week of remote monitoring with a wrist biosensor. Additionally, they will complete a symptom questionnaire to assess autonomic dysfunction. The goal is to identify AD earlier and facilitate remote monitoring, potentially reducing health risks.
Why it matters
Potential benefit: If successful, this approach could lead to earlier identification and management of cardiac autonomic dysfunction in childhood cancer survivors.
How similar studies have gone: Other studies have shown promise in using remote monitoring technologies for various health conditions, suggesting potential success for this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants enrolled in St. Jude Lifetime Cohort (SJLIFE) \>18 years of age. * Primary diagnosis of acute lymphoblastic leukemia (ALL), Hodgkin's Lymphoma (HL), or Non-Hodgkin's Lymphoma (Non-HL). * Not currently taking beta-blocker medication. Exclusion Criteria: * Individuals who cannot speak, read, and/or understand English. * Individuals who are unable to follow directions/instructions in order to complete the Ewing battery. * Individuals with acute heart failure (new or worsening signs and symptoms of heart failure, including a combination of the following: dyspnea, orthopnea, lower limb swelling, elevated jugular venous pressure, and pulmonary congestion). * Women who are currently pregnant.
Where it's running
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St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Kirsten K Ness, PhD — St. Jude Children's Research Hospital
- Study coordinator: Kirsten K Ness, PhD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.