Multi-center pediatric brain and spinal cord tumor treatment network
Official title: Pediatric Brain Tumor Consortium A multi-institutional consortium devoted to novel phase I and II clinical evaluations of experimental treatment approaches for pediatric CNS tumors
Funded at St. Jude Children's Research Hospital · NIH-11466965 · Data updated 2026-11-12
Testing early-phase experimental treatments for children and young adults with brain and spinal cord tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | April 1, 1999 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,423,203 |
| NIH project number | 3UM1CA081457-25S2 |
| Project ID | NIH-11466965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and young adults (typically up to about 21 years old) with brain or spinal cord tumors, particularly those who would be eligible for early-phase experimental treatment trials.
✕Less likely to help
People without central nervous system tumors, and patients looking to join now because most trials are closed to new enrollment, would not benefit from participating.
What this research studies
This consortium brought together major pediatric cancer centers to run phase I and II trials of new treatments for childhood central nervous system tumors. Teams enrolled children and young adults at participating hospitals to try experimental drugs, vaccines, or biologic therapies while monitoring safety and tumor response. As of late 2025, the trials are closed to new enrollment but some participants are still receiving study treatments while researchers finish data review and archive records. Selected studies are being transferred to a new pediatric trials network so promising work can continue.
Why it matters
Potential benefit: If successful, this work could expand treatment options and improve survival or quality of life for children with brain tumors.
How similar studies have gone: Early-phase pediatric brain tumor trials have occasionally produced effective new therapies but many approaches remain experimental and results have been mixed.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Onar-Thomas, Arzu — St. Jude Children's Research Hospital
- Study coordinator: Onar-Thomas, Arzu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.