Multi-center pediatric brain and spinal cord tumor treatment network
Pediatric Brain Tumor Consortium A multi-institutional consortium devoted to novel phase I and II clinical evaluations of experimental treatment approaches for pediatric CNS tumors
['FUNDING_OTHER'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11466965
Testing early-phase experimental treatments for children and young adults with brain and spinal cord tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11466965 on ClinicalTrials.gov |
What this research studies
This consortium brought together major pediatric cancer centers to run phase I and II trials of new treatments for childhood central nervous system tumors. Teams enrolled children and young adults at participating hospitals to try experimental drugs, vaccines, or biologic therapies while monitoring safety and tumor response. As of late 2025, the trials are closed to new enrollment but some participants are still receiving study treatments while researchers finish data review and archive records. Selected studies are being transferred to a new pediatric trials network so promising work can continue.
Who could benefit from this research
Good fit: Children and young adults (typically up to about 21 years old) with brain or spinal cord tumors, particularly those who would be eligible for early-phase experimental treatment trials.
Not a fit: People without central nervous system tumors, and patients looking to join now because most trials are closed to new enrollment, would not benefit from participating.
Why it matters
Potential benefit: If successful, this work could expand treatment options and improve survival or quality of life for children with brain tumors.
How similar studies have performed: Early-phase pediatric brain tumor trials have occasionally produced effective new therapies but many approaches remain experimental and results have been mixed.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ONAR-THOMAS, ARZU — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: ONAR-THOMAS, ARZU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.