Investigating genetic factors affecting drug response in children
Official title: Pharmacogenetic Determinants Of Treatment Response In Children
Run by St. Jude Children's Research Hospital · NCT00730678 · Data updated 2026-11-12
This study is testing how genetic differences in children with serious illnesses affect how they respond to medications to help create more personalized treatments.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 8800 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | August 17, 1998 |
| Main results expected | December 2033 |
| Study ends | March 2034 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT00730678 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include children undergoing treatment at St. Jude Children's Research Hospital and their family members.
✕Probably not a fit
Patients who are not being treated at St. Jude or do not have family members participating may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore how genetic variations influence the metabolism and effects of drugs in children being treated for various malignancies and catastrophic illnesses. By examining family members of patients with specific genetic traits, the study seeks to establish a clearer understanding of heritability and the genetic basis of pharmacogenetic responses. The research focuses on identifying polymorphisms in genes that affect drug metabolism, which can vary significantly across different ethnic groups. The findings could lead to more personalized treatment approaches based on genetic profiles.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of drug treatments in children by tailoring therapies to their genetic profiles.
How similar studies have gone: Previous studies have shown promising results in pharmacogenetics, indicating that this approach could yield significant insights into drug response variability.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patients under evaluation/treatment at St. Jude Children's Research Hospital (SJCRH) * Parents or family members of St. Jude patients * Non patient volunteers * All study subjects must provide informed consent for participation * Assent/Consent of the patient (parent) must be provided prior to attempts made by investigators to enroll a family member of a SJCRH patient Exclusion Criteria:
Where it's running
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St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Jun J Yang, Ph. D. — St. Jude Children's Research Hospital
- Study coordinator: Jun J. Yang, Ph. D.
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.