Investigating frailty and aging in childhood cancer survivors
Official title: Sen-Survivors: An open-label intervention trial for frailty and senescence
Funded at St. Jude Children's Research Hospital · NIH-9890475 · Data updated 2026-11-12
This study is looking at childhood cancer survivors to see how they might face health challenges similar to older adults as they grow up, and it aims to find ways to help them stay strong and healthy by exploring treatments that could improve their well-being.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 1, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2020 |
| Award (this year) | $2,277,711 |
| NIH project number | 1U01CA246510-01 |
| Project ID | NIH-9890475 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are survivors of childhood cancer and may be experiencing signs of frailty.
✕Less likely to help
Patients who are not childhood cancer survivors or those who do not exhibit signs of frailty may not benefit from this research.
What this research studies
This research focuses on childhood cancer survivors who may experience early onset frailty and aging-related health issues as they reach adulthood. It aims to identify the physiological changes associated with frailty, such as low muscle mass and reduced strength, which are typically seen in older adults. The study will explore the role of cellular senescence, a process linked to aging, and how it may be targeted to improve health outcomes in these survivors. Participants may receive interventions involving specific agents that could help mitigate the effects of frailty and promote healthier aging.
Why it matters
Potential benefit: If successful, this research could lead to improved health interventions for childhood cancer survivors, enhancing their quality of life as they age.
How similar studies have gone: Previous research has shown promising results in targeting cellular senescence to improve health outcomes in aging populations, suggesting potential for success in this novel approach.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Armstrong, Gregory — St. Jude Children's Research Hospital
- Study coordinator: Armstrong, Gregory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.