Long-term health outcomes for adults who survived childhood cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital. It will evaluate health outcomes in aging adults who survived pediatric cancer by estimating the prevalence and incidence of late treatment complications. The study will also identify predictors of adverse health outcomes and develop risk profiles based on treatment, genetic, demographic, and psychosocial factors. The research will be conducted in progressive stages, starting with surveys and interviews to understand barriers to participation and inform future recruitment strategies.

Why it matters

Who can join: the full rules

Survivor Inclusion Criteria:

* Patient will have a diagnosis of childhood malignancy (or neoplasm requiring similar therapy) that was treated or followed at St. Jude Children's Research Hospital.
* Patient will be at least five years from diagnosis.
* Patient is willing to participate at any level of study
* Patient is willing to comply with the guidelines of St. Jude domiciliary care facilities
* Patient or legally authorized representative must sign informed consent for study participation.

Control Participant Inclusion Criteria:

* ≥5 years of age
* Non-first degree relatives or friends of St. Jude patients or former patients or SJCRH employees/affiliates who are not SJLIFE study team members, or family members of SJLIFE study team, or supervised by a SJLIFE study team members, or any volunteer not associated with St. Jude.
* Participant does not have a diagnosis of childhood malignancy or childhood neoplasm requiring similar therapy (i.e., diagnosed \<21 years of age).
* Participant is not currently pregnant or lactating.
* Patient is willing to comply with the guidelines of St. Jude domiciliary care facilities.
* Patient must sign informed consent for study participation.

Gait and Mobility Lab Assessment Inclusion Criteria:

* Enrolled participant in the SJLIFE study.
* At-risk for long lasting difficulties with walking or other aspects of mobility.
* Participant is not currently pregnant.
* Participant or their designee signs informed consent for Gait and Mobility Lab Assessment participation.

Survivor/Control Exclusion Criteria:

* Patient or control subject refuses to participate at any level of study

Gait and Mobility Lab Assessment Exclusion Criteria:

* Prospective participant or their designee declines participation in the Gait and Mobility Lab Assessment.

Where it's running

• St. Jude Children's Research Hospital
  Memphis, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Melissa Hudson, MD — St. Jude Children's Research Hospital
• Study coordinator: Melissa Hudson, MD
• Email: referralinfo@stjude.org
• Phone: 888-226-4343

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.