Long-term health outcomes for adults who survived childhood cancer
Establishment of a Lifetime of Cohort of Adults Surviving Childhood Cancer
This study looks at the long-term health of adults who survived childhood cancer to see what health issues they might face as they age and what factors could affect their well-being.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 5 Years and up |
| Sex | All |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Locations | 1 site (Memphis, Tennessee) |
| Trial ID | NCT00760656 on ClinicalTrials.gov |
What this trial studies
This observational study aims to establish a lifetime cohort of childhood cancer survivors treated at St. Jude Children's Research Hospital. It will evaluate health outcomes in aging adults who survived pediatric cancer by estimating the prevalence and incidence of late treatment complications. The study will also identify predictors of adverse health outcomes and develop risk profiles based on treatment, genetic, demographic, and psychosocial factors. The research will be conducted in progressive stages, starting with surveys and interviews to understand barriers to participation and inform future recruitment strategies.
Who should consider this trial
Good fit: Ideal candidates are individuals who were diagnosed with childhood malignancies and are at least five years post-diagnosis.
Not a fit: Patients who do not have a history of childhood malignancy or neoplasm requiring similar therapy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the long-term health risks faced by childhood cancer survivors, leading to improved care and monitoring strategies.
How similar studies have performed: Other studies have shown success in evaluating long-term outcomes in childhood cancer survivors, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
Survivor Inclusion Criteria: * Patient will have a diagnosis of childhood malignancy (or neoplasm requiring similar therapy) that was treated or followed at St. Jude Children's Research Hospital. * Patient will be at least five years from diagnosis. * Patient is willing to participate at any level of study * Patient is willing to comply with the guidelines of St. Jude domiciliary care facilities * Patient or legally authorized representative must sign informed consent for study participation. Control Participant Inclusion Criteria: * ≥5 years of age * Non-first degree relatives or friends of St. Jude patients or former patients or SJCRH employees/affiliates who are not SJLIFE study team members, or family members of SJLIFE study team, or supervised by a SJLIFE study team members, or any volunteer not associated with St. Jude. * Participant does not have a diagnosis of childhood malignancy or childhood neoplasm requiring similar therapy (i.e., diagnosed \<21 years of age). * Participant is not currently pregnant or lactating. * Patient is willing to comply with the guidelines of St. Jude domiciliary care facilities. * Patient must sign informed consent for study participation. Gait and Mobility Lab Assessment Inclusion Criteria: * Enrolled participant in the SJLIFE study. * At-risk for long lasting difficulties with walking or other aspects of mobility. * Participant is not currently pregnant. * Participant or their designee signs informed consent for Gait and Mobility Lab Assessment participation. Survivor/Control Exclusion Criteria: * Patient or control subject refuses to participate at any level of study Gait and Mobility Lab Assessment Exclusion Criteria: * Prospective participant or their designee declines participation in the Gait and Mobility Lab Assessment.
Where this trial is running
Memphis, Tennessee
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Melissa Hudson, MD — St. Jude Children's Research Hospital
- Study coordinator: Melissa Hudson, MD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.