12-week high-intensity interval training for recent survivors of childhood and young-adult Hodgkin lymphoma
Official title: Feasibility of High Intensity Interval Training in Survivors of Childhood, Adolescent, and Young Adult Hodgkin Lymphoma
Run by St. Jude Children's Research Hospital · NCT07222345 · Data updated 2026-11-12
This test tries a 12-week, remotely supervised high-intensity interval training (HIIT) program to see if recently treated survivors of childhood, adolescent, and young adult Hodgkin lymphoma can complete the program and improve fitness and health markers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 10 Years to 25 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | June 8, 2026 |
| Main results expected | January 2028 |
| Study ends | January 2029 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT07222345 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are Hodgkin lymphoma survivors aged over 10 and under 25 at enrollment who finished treatment within the past 24 months, are medically cleared for exercise, and can use the provided web-based platform.
✕Probably not a fit
Patients with relapsed disease, acute heart failure, current pregnancy, those already doing HIIT or more than 420 minutes per week of moderate-to-vigorous activity, or those not medically cleared are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot tests the feasibility of a remotely supervised 12-week HIIT program in survivors who completed Hodgkin lymphoma treatment within the past 24 months. Participants receive an iPad and heart rate monitor and join live web-based HIIT sessions led by exercise physiologists. Researchers conduct baseline and post-intervention assessments including exercise testing, body composition, autonomic function, peripheral neuropathy screening, and blood biomarkers of biological aging. The study will report participation and completion rates and collect preliminary data on cardiorespiratory fitness, physical function, and physical activity.
Why it matters
Potential benefit: If successful, the program could improve cardiorespiratory fitness, body composition, and markers of premature aging in young Hodgkin lymphoma survivors and provide a scalable remote exercise option.
How similar studies have gone: HIIT has shown fitness and cardiovascular benefits in adult cancer survivor studies, but its feasibility and effects have not been well tested in recent survivors from pediatric and young-adult Hodgkin lymphoma.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant has been diagnosed with Hodgkin lymphoma between the ages of 10 to 25 years. * Participant is between the ages of \>10 and \<25 years old the time of enrollment. * Participant has completed treatment (end of chemotherapy for those not receiving radiation therapy or end of radiation therapy) for Hodgkin lymphoma within 24 months prior to enrollment and recovered from any acute treatment-related adverse events. * Participant has been medically cleared to participate in physical activity. * Participant verbalizes understanding of directions for use of the web-based platform on the study provided iPad and heart rate monitor. Exclusion Criteria: * Participant has evidence of relapsed disease. * Participant has a diagnosis of acute heart failure. * Participant reports currently participating in HIIT training or \>420 minutes per week of moderate to vigorous physical activity. * Female participant who is currently pregnant.
Where it's running
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St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Amy Berkman, MD — St. Jude Children's Research Hospital
- Study coordinator: Amy Berkman, MD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.