Molecular analysis of pediatric solid tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize the molecular, cellular, and genetic properties of various pediatric solid tumors, including neuroblastoma, osteosarcoma, and retinoblastoma. It will involve collecting tumor specimens for gene expression analysis, genomic profiling, and next-generation sequencing. Additionally, the study will examine T cell receptor specificity and perform epigenetic studies to understand the anti-tumor response. The goal is to identify changes in gene expression and correlate them with genetic alterations to improve treatment strategies for these aggressive cancers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Must have a suspected or known diagnosis of neuroblastoma, osteosarcoma, Ewing sarcoma family of tumor or soft tissue sarcoma based on the initial diagnostic workup and evidence of gross disease amenable to excision. Specimens may be collected at some or all of the following time points: initial biopsy, bone marrow aspiration procedures, tumor resection, and at time of possible relapse.
* Patients with a diagnosis of retinoblastoma based on initial diagnostic workup and who require enucleation may be enrolled if there is no active therapeutic or biologic protocol for retinoblastoma.
* The patient or his/her legal guardian, as appropriate, must provide written informed consent within 30 days of the removal of the first collection of tissue/bone marrow/blood sample for this protocol.
* The patient is being seen at St. Jude Children's Research Hospital or at a collaborating institution.
* Patients must be less than or equal to 25 years old at the time of enrollment.

Exclusion Criteria:

* Patient is known to be Hepatitis B, Hepatitis C and/or HIV positive.

Where it's running

• St. Jude Children's Research Hospital
  Memphis, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Sara M. Federico, MD — St. Jude Children's Research Hospital
• Study coordinator: Sara M. Federico, MD
• Email: referralinfo@stjude.org
• Phone: 1-866-278-5833

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.