Transition outcomes for adolescents and young adults with a cancer predisposition.
Official title: Outcomes of Health Care Transition for AYA With a Cancer Predisposition
Run by St. Jude Children's Research Hospital · NCT07456904 · Data updated 2026-11-12
See if young adults with a genetic cancer predisposition establish and keep up care with adult providers and follow recommended cancer surveillance after they leave pediatric care at St. Jude.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 56 (estimated) |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Locations | 1 site (Memphis, Tennessee) |
| Status | Recruiting |
| Started | June 16, 2026 |
| Main results expected | November 2034 |
| Study ends | November 2037 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT07456904 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) who were patients of St. Jude’s Cancer Predisposition Clinic for at least three years, have a molecular or clinical CPS with adult surveillance recommendations, are graduating or have graduated from SJCRH, can consent for themselves, and are fluent in English.
✕Probably not a fit
People who are not their own medical decision-makers, who do not have a CPS requiring adult surveillance, who were not treated at St. Jude, or who cannot complete English surveys may not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational cohort follows adolescents and young adults (AYAs) with a molecular or clinical cancer predisposition syndrome who are graduating or have graduated from St. Jude Children’s Research Hospital. Participants complete a Readiness Assessment one month after graduation and electronic Transition Outcomes Surveys at 1, 3, 5, and 8 years to record establishment and maintenance of adult care and adherence to CPS-specific surveillance. Surveys also collect information on barriers and facilitators to care, psychosocial experiences, and adherence to recommended screening. The study will explore clinical and demographic factors associated with successful transition and long-term surveillance adherence.
Why it matters
Potential benefit: If successful, the results could help tailor transition support so more young adults with CPS keep adult care and complete recommended cancer surveillance.
How similar studies have gone: Transition programs for chronic pediatric conditions have shown mixed but often positive effects on adult care engagement, while CPS-specific long-term outcome data are limited so this approach is relatively novel for this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants are ≥18 years of age * Participants with a molecular or clinical diagnosis of a Cancer Predisposition Syndrome (CPS) who are graduating or have graduated from SJCRH. * Participants who were a patient of the SJCRH Cancer Predisposition Clinic for at least 3 years before graduating from SJCRH * Participants who require cancer/tumor surveillance within 1 year after graduation from SJCRH. Required cancer/tumor surveillance in adulthood is defined as having a CPS with expert guidelines recommending cancer/tumor surveillance in adulthood * Participants fluent in English. Exclusion Criteria: * Participants who are not their own legal medical decision-maker.
Where it's running
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St. Jude Children's Research Hospital
Memphis, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Melissa R Perrino, MD — St. Jude Children's Research Hospital
- Study coordinator: Melissa R Perrino, MD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.