Transition outcomes for adolescents and young adults with a cancer predisposition.
Outcomes of Health Care Transition for AYA With a Cancer Predisposition
See if young adults with a genetic cancer predisposition establish and keep up care with adult providers and follow recommended cancer surveillance after they leave pediatric care at St. Jude.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 56 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Locations | 1 site (Memphis, Tennessee) |
| Trial ID | NCT07456904 on ClinicalTrials.gov |
What this trial studies
This observational cohort follows adolescents and young adults (AYAs) with a molecular or clinical cancer predisposition syndrome who are graduating or have graduated from St. Jude Children’s Research Hospital. Participants complete a Readiness Assessment one month after graduation and electronic Transition Outcomes Surveys at 1, 3, 5, and 8 years to record establishment and maintenance of adult care and adherence to CPS-specific surveillance. Surveys also collect information on barriers and facilitators to care, psychosocial experiences, and adherence to recommended screening. The study will explore clinical and demographic factors associated with successful transition and long-term surveillance adherence.
Who should consider this trial
Good fit: Adults (≥18) who were patients of St. Jude’s Cancer Predisposition Clinic for at least three years, have a molecular or clinical CPS with adult surveillance recommendations, are graduating or have graduated from SJCRH, can consent for themselves, and are fluent in English.
Not a fit: People who are not their own medical decision-makers, who do not have a CPS requiring adult surveillance, who were not treated at St. Jude, or who cannot complete English surveys may not benefit from the findings.
Why it matters
Potential benefit: If successful, the results could help tailor transition support so more young adults with CPS keep adult care and complete recommended cancer surveillance.
How similar studies have performed: Transition programs for chronic pediatric conditions have shown mixed but often positive effects on adult care engagement, while CPS-specific long-term outcome data are limited so this approach is relatively novel for this population.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants are ≥18 years of age * Participants with a molecular or clinical diagnosis of a Cancer Predisposition Syndrome (CPS) who are graduating or have graduated from SJCRH. * Participants who were a patient of the SJCRH Cancer Predisposition Clinic for at least 3 years before graduating from SJCRH * Participants who require cancer/tumor surveillance within 1 year after graduation from SJCRH. Required cancer/tumor surveillance in adulthood is defined as having a CPS with expert guidelines recommending cancer/tumor surveillance in adulthood * Participants fluent in English. Exclusion Criteria: * Participants who are not their own legal medical decision-maker.
Where this trial is running
Memphis, Tennessee
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Melissa R Perrino, MD — St. Jude Children's Research Hospital
- Study coordinator: Melissa R Perrino, MD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.