Evaluating the impact of artery calcification on stroke treatment outcomes
Official title: The Prediction of Intracranial Artery Calcification on Adverse Outcomes of Large Vessel Occlusive, Acute Ischemic Stroke Patients After Mechanical Thrombectomy: A Prospective Cohort, Observational Study
Run by Zhujiang Hospital · NCT06418698 · Data updated 2026-11-12
This study is trying to see if the amount of calcium in the arteries affects how well stroke patients do after a specific treatment for blocked blood vessels.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 434 (estimated) |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | March 28, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | June 2029 |
| Registry record updated | July 28, 2025 |
| Trial ID | NCT06418698 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years with acute ischemic stroke symptoms and confirmed large or medium vessel occlusion.
✕Probably not a fit
Patients with neurologic deficits from conditions other than ischemic stroke or those with acute ischemic stroke occurring more than 24 hours prior will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the relationship between intracranial artery calcification (IAC) and the outcomes of endovascular treatment (EVT) in patients suffering from acute ischemic stroke due to large or medium vessel occlusion. By utilizing the Agatston score to quantify IAC, the study seeks to predict adverse angiographic and functional outcomes following EVT. The findings will help in risk stratification and may guide personalized treatment plans for affected patients.
Why it matters
Potential benefit: If successful, this study could enhance the ability to predict treatment outcomes for stroke patients, leading to more tailored and effective interventions.
How similar studies have gone: While the correlation between artery calcification and stroke outcomes is being explored, this specific approach using the Agatston score in the context of EVT is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or non-pregnant women with acute stroke symptoms aged over 18 years. * Occlusion of the intracranial internal carotid artery, the middle cerebral artery, the anterior cerebral artery, the posterior cerebral artery, basilar artery and intracranial vertebral artery confirmed by CT, MR angiography, or digital subtraction angiography. * No absolute contraindication to iodinated contrast media. * Planned treatment with EVT by clinical care team. * Informed consent obtained from patients or their legal representatives. * Willing to be followed up as required by the clinical study protocol. Exclusion Criteria: * Acute ischemic stroke occurs over 24 hours of time last known well. * Neurologic deficits caused by diagnoses other than ischemic stroke, such as intracerebral hemorrhage, subarachnoid hemorrhage, or intracranial tumors. * With other underlying factors leading to IAC, such as hyperthyroidism, end-stage renal disease, long-term oral intake of vitamin K antagonist(Warfarin), chronic vitamin D deficiency or overdose, persistent hypomagnesemia, persistent hypercalcemia, persistent hyperphosphatemia and high oral calcium intake. * Lack of non-contract CT images on admission and significant artifacts in CT images preventing IAC measurement. * Severe renal insufficiency (estimated glomerular filtration rate \< 30ml/min or serum creatinine \> 220μmol/L (2.5mg/dl)). * Previous cerebrovascular intervention treatment or craniotomy.
Where it's running
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Zhujiang Hospital, Southern Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Duan Chuanzhi, MD — Zhujiang Hospital
- Study coordinator: Feng Xin, MD
- Email: 13681134001@163.com
- Phone: +8613681134001
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This trial will test whether a portable dry‑electrode EEG headset (StrokePointer) can detect large vessel occlusion strokes in adults with suspected acute stroke so ambulance crews can take them directly to hospitals that perform thrombectomy.
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This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.