Investigating blood vessel changes during pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to compare the vascular adaptations in pregnant women with and without preeclampsia by collecting omental and placental tissue during cesarean sections. The research will focus on the expression and activation of the AT2 receptor and its role in vascular function and dysfunction. A total of up to 114 pregnant women will be enrolled, with the option to provide one or both types of tissue specimens. The study will analyze the collected samples to understand fetal vascular dysfunction associated with preeclampsia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female
* Ages 18 to 40 years old
* Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent
* Undergoing caesarean section, either planned or otherwise with or without trial of labor

Exclusion Criteria:

* Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
* Any major fetal structural anomalies or aneuploidies
* Undergoing cesarean section for placental abruption or bleeding complications.
* Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)

Where it's running

• UnityPoint Health-Meriter Hospital
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Sathish Kumar, PhD — University of Wisconsin, Madison
• Study coordinator: UW Ob/Gyn Human Subjects Core
• Email: research.crc_obgyn@wisc.edu
• Phone: 608-890-3345

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.