Evaluating therapy for patients with minor strokes and large vessel occlusion
Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion: A Prospective Multicenter Registry Study
This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sir Run Run Shaw Hospital Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06633809 on ClinicalTrials.gov |
What this trial studies
This multicenter registry study focuses on acute ischemic stroke patients who present with low NIHSS scores and large vessel occlusion. The study aims to gather data on therapy strategies and follow up on these patients to evaluate their outcomes. It seeks to identify predictors of neurological deterioration and determine the most effective treatment approaches for this specific patient population. By analyzing the results, the study hopes to improve prognostic predictions and therapy evaluations for patients with minor strokes and large vessel occlusions.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who have experienced an acute ischemic stroke with a low NIHSS score and proximal intracranial artery occlusion.
Not a fit: Patients with signs of intracranial hemorrhage, seizures at stroke onset, or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with minor strokes, potentially enhancing their recovery and outcomes.
How similar studies have performed: While there is limited data on this specific approach, similar studies have indicated the importance of tailored therapy strategies for minor stroke patients with large vessel occlusion.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged 18 years or older 2. Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset 3. Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel 4. Baseline ASPECTS ≥6 or infarct Core Volume of \< 70 on NCCT/DWI/CTP 5. Pre-mRS≤1 Exclusion Criteria: 1. Any sign of intracranial hemorrhage on baseline CT/MR; 2. Seizures at stroke onset 3. Baseline blood glucose of \<2.78 mmol or \>22.20 mmol, or platelet count \< 100,000/uL or serum creatinine levels \> 3.0 mg/dL 4. Participation in any investigational study in the previous 30 days
Where this trial is running
Hangzhou, Zhejiang
- Sir Run Run Shaw Hospital — Hangzhou, Zhejiang, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.