Evaluating therapy for patients with minor strokes and large vessel occlusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter registry study focuses on acute ischemic stroke patients who present with low NIHSS scores and large vessel occlusion. The study aims to gather data on therapy strategies and follow up on these patients to evaluate their outcomes. It seeks to identify predictors of neurological deterioration and determine the most effective treatment approaches for this specific patient population. By analyzing the results, the study hopes to improve prognostic predictions and therapy evaluations for patients with minor strokes and large vessel occlusions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 18 years or older
2. Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset
3. Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel
4. Baseline ASPECTS ≥6 or infarct Core Volume of \< 70 on NCCT/DWI/CTP
5. Pre-mRS≤1

Exclusion Criteria:

1. Any sign of intracranial hemorrhage on baseline CT/MR;
2. Seizures at stroke onset
3. Baseline blood glucose of \<2.78 mmol or \>22.20 mmol, or platelet count \< 100,000/uL or serum creatinine levels \> 3.0 mg/dL
4. Participation in any investigational study in the previous 30 days

Where it's running

• Sir Run Run Shaw Hospital
  Hangzhou, Zhejiang, China Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Video call assessment for suspected stroke

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• Monitoring brain-derived tau levels in acute ischemic stroke patients

  This study is testing how brain-derived tau levels change in stroke patients over 48 hours to see if it can help understand their condition and improve treatment decisions.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT06121336

• Intra-arterial clot-dissolving treatment for medium-vessel ischemic stroke

  The team will test whether giving tenecteplase directly into the artery helps adults with acute ischemic stroke caused by medium-vessel blockage or severe narrowing.

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• Endovascular treatment for stroke beyond 24 hours

  This study is testing whether a specific stroke treatment can help people who have had a stroke more than 24 hours ago feel better and regain independence compared to just receiving standard care.

  Recruiting The Second Hospital of Anhui Medical University · Hefei, Anhui · NCT06959199

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.