Using low-dose aspirin after preeclampsia to improve recovery
Treatment With Aspirin After Preeclampsia: TAP Trial
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Female |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT06281665 on ClinicalTrials.gov |
What this trial studies
This pilot trial aims to evaluate the feasibility and effects of low-dose aspirin on vascular recovery in postpartum individuals who have experienced preeclampsia. Participants will be randomly assigned to receive either 81mg of low-dose aspirin or a placebo daily for six months after delivery. The study will involve monitoring blood pressure, conducting blood draws, and assessing endothelial function through microiontophoresis at multiple visits. The goal is to determine if aspirin can improve endothelial function and lower blood pressure in this population.
Who should consider this trial
Good fit: Ideal candidates are postpartum individuals aged 18 and older who have been diagnosed with preeclampsia.
Not a fit: Patients with pre-pregnancy hypertension, diabetes, or contraindications to aspirin will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance recovery and reduce long-term cardiovascular risks for women who have had preeclampsia.
How similar studies have performed: While the use of aspirin in pregnancy has been studied, this specific approach focusing on postpartum recovery after preeclampsia is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Postpartum individuals ≥18 years old * Preeclampsia diagnosis Exclusion Criteria: * Fetal anomaly * Multiple gestation * Pre-pregnancy hypertension * Allergy or contraindication to low-dose aspirin * Pre-pregnancy diabetes
Where this trial is running
Pittsburgh, Pennsylvania
- University of Pittsburgh Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Alisse K Hauspurg, MD — UPMC Magee Women's Hospital
- Study coordinator: Alisse K Hauspurg, MD
- Email: janickia@upmc.edu
- Phone: 412-641-1381
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.