Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 to 55 Women only

Using low-dose aspirin after preeclampsia to improve recovery

Official title: Treatment With Aspirin After Preeclampsia: TAP Trial

Run by University of Pittsburgh · NCT06281665 · Data updated 2026-11-12

This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 55 Years
SexWomen only
Enrollment60 (estimated)
SponsorUniversity of Pittsburgh
Academic / other
Locations1 site (Pittsburgh, Pennsylvania)
StatusRecruiting
StartedMay 29, 2024
Main results expectedJanuary 1, 2027
Study endsOctober 1, 2027
Registry record updatedSeptember 22, 2026
Trial IDNCT06281665 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are postpartum individuals aged 18 and older who have been diagnosed with preeclampsia.

Probably not a fit

Patients with pre-pregnancy hypertension, diabetes, or contraindications to aspirin will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial aims to evaluate the feasibility and effects of low-dose aspirin on vascular recovery in postpartum individuals who have experienced preeclampsia. Participants will be randomly assigned to receive either 81mg of low-dose aspirin or a placebo daily for six months after delivery. The study will involve monitoring blood pressure, conducting blood draws, and assessing endothelial function through microiontophoresis at multiple visits. The goal is to determine if aspirin can improve endothelial function and lower blood pressure in this population.

Why it matters

Potential benefit: If successful, this approach could enhance recovery and reduce long-term cardiovascular risks for women who have had preeclampsia.

How similar studies have gone: While the use of aspirin in pregnancy has been studied, this specific approach focusing on postpartum recovery after preeclampsia is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Postpartum individuals ≥18 years old
* Preeclampsia diagnosis

Exclusion Criteria:

* Fetal anomaly
* Multiple gestation
* Pre-pregnancy hypertension
* Allergy or contraindication to low-dose aspirin
* Pre-pregnancy diabetes

Where it's running

  • University of Pittsburgh Magee-Womens Hospital
    Pittsburgh, Pennsylvania, United States
    Recruiting

Study contacts

  • Principal investigator: Alisse K Hauspurg, MD — UPMC Magee Women's Hospital
  • Study coordinator: Alisse K Hauspurg, MD
  • Email: janickia@upmc.edu
  • Phone: 412-641-1381

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.