Using low-dose aspirin after preeclampsia to improve recovery
Official title: Treatment With Aspirin After Preeclampsia: TAP Trial
Run by University of Pittsburgh · NCT06281665 · Data updated 2026-11-12
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 55 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | May 29, 2024 |
| Main results expected | January 1, 2027 |
| Study ends | October 1, 2027 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT06281665 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are postpartum individuals aged 18 and older who have been diagnosed with preeclampsia.
✕Probably not a fit
Patients with pre-pregnancy hypertension, diabetes, or contraindications to aspirin will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot trial aims to evaluate the feasibility and effects of low-dose aspirin on vascular recovery in postpartum individuals who have experienced preeclampsia. Participants will be randomly assigned to receive either 81mg of low-dose aspirin or a placebo daily for six months after delivery. The study will involve monitoring blood pressure, conducting blood draws, and assessing endothelial function through microiontophoresis at multiple visits. The goal is to determine if aspirin can improve endothelial function and lower blood pressure in this population.
Why it matters
Potential benefit: If successful, this approach could enhance recovery and reduce long-term cardiovascular risks for women who have had preeclampsia.
How similar studies have gone: While the use of aspirin in pregnancy has been studied, this specific approach focusing on postpartum recovery after preeclampsia is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Postpartum individuals ≥18 years old * Preeclampsia diagnosis Exclusion Criteria: * Fetal anomaly * Multiple gestation * Pre-pregnancy hypertension * Allergy or contraindication to low-dose aspirin * Pre-pregnancy diabetes
Where it's running
-
University of Pittsburgh Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Alisse K Hauspurg, MD — UPMC Magee Women's Hospital
- Study coordinator: Alisse K Hauspurg, MD
- Email: janickia@upmc.edu
- Phone: 412-641-1381
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.