Understanding long-term heart health in women after hypertensive pregnancies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate why women who have experienced high blood pressure during pregnancy are at an increased risk of developing cardiovascular diseases later in life. By analyzing data from women 10 to 25 years postpartum, the study will assess changes in the heart, brain, and blood vessels over time. The researchers will compare women with hypertensive pregnancies to those with normotensive pregnancies to identify patterns of disease progression. Advanced imaging and machine learning models will be utilized to understand the interconnectedness of these changes across different body systems.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion Criteria

  * Participant is willing and able to give informed consent for participation in the study
  * Female who had a pregnancy 10 to 25 years prior
  * Able (in the investigator's opinion) and willing to comply with all study requirements.
  * Adequate understanding of verbal and written English

Exclusion Criteria:

* The participant may not enter the study if ANY of the following apply:

  * Over 10 weeks pregnant during the course of the study
  * Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status
  * Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study

For exclusion of MRI component only:

• Unsuitable for MRI based on the responses to the MRI screening form. The participant may still be included in other parts of the study.

Where it's running

• University of Oxford Department of Cardiovascular Medicine
  Oxford, United Kingdom Recruiting

Study contacts

• Principal investigator: Paul Leeson — University of Oxford
• Study coordinator: Katie Suriano
• Email: helpful@cardiov.ox.ac.uk
• Phone: 01865226845

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.