Understanding how mitochondrial problems affect eye blood vessel diseases
Investigating the role of mitochondrial dysfunction in the pathogenesis of retinal vascular diseases
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10887541
This study is looking at how problems with tiny energy factories in our cells, called mitochondria, might affect blood vessel growth in the eye, which is important for people with conditions like diabetic retinopathy, to help find new ways to treat these eye diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10887541 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial dysfunction in the development of retinal vascular diseases, which are conditions affecting the blood vessels in the eye. The study focuses on how mitochondrial proteins influence the process of angiogenesis, or the formation of new blood vessels, which can be impaired or excessive in diseases like diabetic retinopathy. By using advanced in vitro models and genetically modified mice, the researchers aim to uncover the mechanisms by which mitochondrial activity impacts endothelial cell behavior and retinal blood vessel growth. This could lead to new insights into potential therapeutic targets for these eye diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with retinal vascular diseases such as diabetic retinopathy or familial exudative vitreoretinopathy.
Not a fit: Patients with retinal conditions not related to vascular issues or those without mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for retinal vascular diseases, potentially improving vision and quality of life for affected patients.
How similar studies have performed: Previous research has shown that targeting mitochondrial function can influence angiogenesis, suggesting that this approach may yield promising results.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, JENNY HUANJIAO — YALE UNIVERSITY
- Study coordinator: ZHOU, JENNY HUANJIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.