Clinical trial Recruiting at 1 site Observational Ages 18 and up

Heart assessment to check repeat-stroke risk in people with atrial fibrillation

Official title: CARE-AF: Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation

Run by Insel Gruppe AG, University Hospital Bern · NCT06954610 · Data updated 2026-11-12

This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.

More Stroke trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment500 (estimated)
SponsorInsel Gruppe AG, University Hospital Bern
Academic / other
Locations1 site (Bern)
StatusRecruiting
StartedNovember 4, 2025
Main results expectedJune 30, 2028
Study endsJune 30, 2028
Registry record updatedNovember 20, 2025
Trial IDNCT06954610 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18 years) with permanent, persistent, or paroxysmal atrial fibrillation and an acute (≤7 days) symptomatic ischemic stroke who can give informed consent are ideal candidates.

Probably not a fit

People without atrial fibrillation, without a recent ischemic stroke, those with life expectancy under one year, or those unable to attend follow-up visits are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort enrolls adults with known or newly diagnosed atrial fibrillation who present with an acute ischemic stroke within seven days. Participants receive detailed cardiac evaluations (for example cardiac imaging, rhythm monitoring, and review of anticoagulation) and clinical data are collected. Patients are followed over time for recurrent stroke and related outcomes without changing prescribed treatments. The goal is to identify cardiac features linked to so-called "breakthrough" strokes despite anticoagulation.

Why it matters

Potential benefit: If successful, the results could help clinicians identify high-risk patients and guide closer monitoring or targeted interventions to prevent repeat strokes.

How similar studies have gone: Previous trials of anticoagulants documented a residual risk of breakthrough stroke and some observational work has suggested cardiac markers may predict recurrence, but clear, validated predictors are still lacking.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 18 years
* Written informed consent (by patient, next of kin or legally authorised representative)
* Permanent, persistent, or paroxysmal AF previously known or diagnosed during the index hospitalisation
* Acute (≤7 days), symptomatic ischemic stroke

Exclusion Criteria:

* Life expectancy \<1 year according to the opinion of the investigator
* Patient is unlikely to attend follow-up visits

Where it's running

  • Inselspital Bern
    Bern, Switzerland
    Recruiting

Study contacts

  • Principal investigator: David Seiffge, Prof. MD — Department of Neurology, Inselspital, University Hospital Bern, Switzerland
  • Study coordinator: David Seiffge, Prof. MD
  • Email: david.seiffge@insel.ch
  • Phone: +41316640509

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.