Heart assessment to check repeat-stroke risk in people with atrial fibrillation
Official title: CARE-AF: Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation
Run by Insel Gruppe AG, University Hospital Bern · NCT06954610 · Data updated 2026-11-12
This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 1 site (Bern) |
| Status | Recruiting |
| Started | November 4, 2025 |
| Main results expected | June 30, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | November 20, 2025 |
| Trial ID | NCT06954610 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with permanent, persistent, or paroxysmal atrial fibrillation and an acute (≤7 days) symptomatic ischemic stroke who can give informed consent are ideal candidates.
✕Probably not a fit
People without atrial fibrillation, without a recent ischemic stroke, those with life expectancy under one year, or those unable to attend follow-up visits are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational cohort enrolls adults with known or newly diagnosed atrial fibrillation who present with an acute ischemic stroke within seven days. Participants receive detailed cardiac evaluations (for example cardiac imaging, rhythm monitoring, and review of anticoagulation) and clinical data are collected. Patients are followed over time for recurrent stroke and related outcomes without changing prescribed treatments. The goal is to identify cardiac features linked to so-called "breakthrough" strokes despite anticoagulation.
Why it matters
Potential benefit: If successful, the results could help clinicians identify high-risk patients and guide closer monitoring or targeted interventions to prevent repeat strokes.
How similar studies have gone: Previous trials of anticoagulants documented a residual risk of breakthrough stroke and some observational work has suggested cardiac markers may predict recurrence, but clear, validated predictors are still lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Written informed consent (by patient, next of kin or legally authorised representative) * Permanent, persistent, or paroxysmal AF previously known or diagnosed during the index hospitalisation * Acute (≤7 days), symptomatic ischemic stroke Exclusion Criteria: * Life expectancy \<1 year according to the opinion of the investigator * Patient is unlikely to attend follow-up visits
Where it's running
-
Inselspital Bern
Bern, Switzerland Recruiting
Study contacts
- Principal investigator: David Seiffge, Prof. MD — Department of Neurology, Inselspital, University Hospital Bern, Switzerland
- Study coordinator: David Seiffge, Prof. MD
- Email: david.seiffge@insel.ch
- Phone: +41316640509
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating the impact of artery calcification on stroke treatment outcomes
This study is trying to see if the amount of calcium in the arteries affects how well stroke patients do after a specific treatment for blocked blood vessels.
-
Intra-arterial clot-dissolving treatment for medium-vessel ischemic stroke
The team will test whether giving tenecteplase directly into the artery helps adults with acute ischemic stroke caused by medium-vessel blockage or severe narrowing.
-
Endovascular treatment for stroke beyond 24 hours
This study is testing whether a specific stroke treatment can help people who have had a stroke more than 24 hours ago feel better and regain independence compared to just receiving standard care.
-
Portable EEG to triage suspected stroke patients in ambulances
This trial will test whether a portable dry‑electrode EEG headset (StrokePointer) can detect large vessel occlusion strokes in adults with suspected acute stroke so ambulance crews can take them directly to hospitals that perform thrombectomy.
-
Evaluating therapy for patients with minor strokes and large vessel occlusion
This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.
-
Video call assessment for suspected stroke
This study tests if using video calls between neurologists and emergency responders can help quickly and accurately assess patients who might be having a stroke.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.