Investigating inflammation's role in vascular disease
The Role of Inflammation in Vascular Disease (Inflammationens Roll i kärlsjukdom)
This study is trying to see how low-grade inflammation affects heart and blood vessel problems in patients having vascular surgeries compared to those having other types of surgeries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 170 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Göteborg University Academic / other |
| Locations | 1 site (Gothenburg, Vastragotaland) |
| Trial ID | NCT03732612 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the connection between systemic low-grade inflammation and various cardiovascular conditions, including vascular dysfunction and atherosclerosis. Patients undergoing vascular surgeries will have excised tissue collected for research purposes, which will be cultured to assess the effects of therapeutic agents on inflammation. The study will also include control patients who have undergone unrelated surgeries to compare the findings. The goal is to better understand how inflammation contributes to vascular diseases.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for vascular surgery related to peripheral arterial diseases or atherosclerosis.
Not a fit: Patients under 18 years of age or those participating in drug-related studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing vascular diseases and improving patient outcomes.
How similar studies have performed: While the role of inflammation in cardiovascular disease has been studied, this specific approach of utilizing excised vascular tissue for research is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient is planned to undergo vascular surgery. * Signed informed consent has been obtained from the patient. Exclusion Criteria: * Patient has difficulty to understand information. * Patients under 18 years of age. * Patients participating in any drug-related study.
Where this trial is running
Gothenburg, Vastragotaland
- University of Gothenburg — Gothenburg, Vastragotaland, Sweden (Recruiting)
Study contacts
- Study coordinator: Emma Borgeson, PhD
- Email: emma.borgeson@wlab.gu.se
- Phone: +46313420000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.