Understanding how social factors affect cognitive function after stroke
Official title: Understanding Stroke Outcomes: Stroke Resilience, Infarct Burden, and Long-Term Cognition
Run by National Institutes of Health Clinical Center (CC) · NCT06615973 · Data updated 2026-11-12
This study looks at how social factors, like support from family and friends, affect how well people recover mentally after having a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 450 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | September 14, 2026 |
| Main results expected | February 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT06615973 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have previously participated in the Natural History of Stroke study and have an interpretable MRI scan.
✕Probably not a fit
Patients who have a modified Rankin Scale score of 6, indicating death, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the impact of social determinants of health (SDOH) on cognitive function in individuals who have experienced a stroke. Participants, aged 18 and older, will be recruited from a previous study and will engage in a 45-minute telephone interview to discuss their health and social factors since their stroke. The study will analyze how these social factors relate to the severity of brain damage as measured by MRI and their influence on post-stroke recovery outcomes. The goal is to identify characteristics that may enhance resilience and improve recovery after a stroke.
Why it matters
Potential benefit: If successful, this study could provide insights that help improve cognitive outcomes for stroke survivors by addressing social factors.
How similar studies have gone: While studies have explored the impact of social factors on health, this specific approach focusing on post-stroke cognitive function is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study. * Adults aged 18 or older. * Previous participant in the Natural History of Stroke with an interpretable baseline MRI scan, NIHSS measured at baseline or discharge, and admission diagnosis of ischemic stroke. * Fluent in English or Spanish EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: -Modified Rankin Scale (mRS) = 6 at any follow-up (usually up to 90 days) in the Natural History of Stroke study (mRS = 6 indicates the participant is dead).
Where it's running
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Rebecca F Gottesman, M.D. — National Institute of Neurological Disorders and Stroke (NINDS)
- Study coordinator: Rebecca F Gottesman, M.D.
- Email: rebecca.gottesman@nih.gov
- Phone: (301) 435-9321
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.