Investigating the role of a protein in blood vessel diseases
Official title: The uncharacterized nuclear protein HMGXB4 in occlusive vascular diseases
Funded at Augusta University · NIH-10985592 · Data updated 2026-11-12
This study is looking at how a protein called HMGXB4 affects certain cells in your blood vessels, which could help us understand and find better ways to treat conditions like atherosclerosis and restenosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $135,000 |
| NIH project number | 1K99HL171834-01A1 |
| Project ID | NIH-10985592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with occlusive vascular diseases, such as atherosclerosis or coronary artery disease.
✕Less likely to help
Patients with non-vascular related conditions or those not at risk for occlusive vascular diseases may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein, HMGXB4, affects the behavior of vascular smooth muscle cells (VSMCs) in occlusive vascular diseases like atherosclerosis and restenosis. By studying how HMGXB4 influences the transition of VSMCs from a contractile state to a proliferative state, researchers aim to uncover the mechanisms behind these diseases. The approach includes analyzing samples from both humans and mice to see how HMGXB4 expression correlates with inflammation and disease progression. This could lead to new therapeutic strategies for managing vascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent occlusive vascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the roles of similar proteins in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: He, Xiangqin — Augusta University
- Study coordinator: He, Xiangqin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.