Understanding genetic factors in Alzheimer's and vascular diseases
Official title: Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases
Funded at Duke University · NIH-10769801 · Data updated 2026-11-12
This study is looking at how both genes and other factors affect the chances of developing Alzheimer's and related conditions, so we can better understand individual risks and create more tailored ways to help people at different ages.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | February 15, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $724,986 |
| NIH project number | 5R01AG065477-05 |
| Project ID | NIH-10769801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or vascular conditions, as well as those showing early signs of cognitive decline.
✕Less likely to help
Patients with confirmed diagnoses of advanced Alzheimer's disease or those with unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates how genetic and non-genetic factors contribute to the risk and resilience of Alzheimer's disease and related vascular conditions. By analyzing large samples and utilizing advanced genetic methodologies, the project aims to identify unique risk profiles for individuals. This approach seeks to disentangle the complex interactions between various risk factors, which can lead to more personalized interventions. The research also considers age-specific effects, enhancing the understanding of how these diseases manifest differently across different life stages.
Why it matters
Potential benefit: If successful, this research could lead to more tailored and effective interventions for individuals at risk of Alzheimer's and vascular diseases.
How similar studies have gone: Previous research has shown promise in using genetic profiling to understand Alzheimer's disease, indicating that this approach could yield significant insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kulminski, Alexander M — Duke University
- Study coordinator: Kulminski, Alexander M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.