Understanding cardiovascular risks in young adults born to hypertensive pregnancies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the cardiovascular health of individuals in their 20s and 30s who were born to mothers with hypertension during pregnancy. It seeks to identify the long-term effects of hypertensive pregnancies on blood pressure and heart disease risk in these individuals. By analyzing changes in the heart, blood vessels, and brain, the study hopes to uncover patterns that could predict future cardiovascular issues. The findings may lead to new prevention strategies for early onset heart and blood vessel diseases in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study
* Male or female, aged 30 to 40 years at time of enrolment
* Participant previously took part in the ALSPAC study
* Able (in the investigator's opinion) and willing to comply with all study requirements
* Adequate understanding of verbal and written English

Exclusion Criteria:

* Pregnant or lactating when they are due to attend for study visit 1
* Less than six months postpartum
* Planning to donate blood within two weeks prior to study visit 1
* Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study
* Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status

For exclusion of MRI component only:

* Unsuitable for MRI based on participant screening; the participant may still be included in other parts of the study

Where it's running

• University of Oxford
  Oxford, Oxfordshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Adam J Lewandowski — Cardiovascular Clinical Research Facility
• Study coordinator: Katie Suriano
• Email: clarity@cardiov.ox.ac.uk
• Phone: 01865 226845

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.