Understanding cardiovascular risks in young adults born to hypertensive pregnancies
Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood
This study is looking at the heart health of young adults in their 20s and 30s who were born to mothers with high blood pressure during pregnancy to see if it affects their risk of heart problems later on.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 30 Years to 40 Years |
| Sex | All |
| Sponsor | University of Oxford Academic / other |
| Locations | 1 site (Oxford, Oxfordshire) |
| Trial ID | NCT05683093 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the cardiovascular health of individuals in their 20s and 30s who were born to mothers with hypertension during pregnancy. It seeks to identify the long-term effects of hypertensive pregnancies on blood pressure and heart disease risk in these individuals. By analyzing changes in the heart, blood vessels, and brain, the study hopes to uncover patterns that could predict future cardiovascular issues. The findings may lead to new prevention strategies for early onset heart and blood vessel diseases in this population.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 30 to 40 who were born to hypertensive pregnancies and previously participated in the ALSPAC study.
Not a fit: Patients who are currently pregnant, lactating, or have significant chronic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention strategies for cardiovascular diseases in young adults who were born to hypertensive pregnancies.
How similar studies have performed: Previous studies have indicated that understanding the long-term effects of hypertensive pregnancies can reveal significant cardiovascular risks, suggesting this approach has merit.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Male or female, aged 30 to 40 years at time of enrolment * Participant previously took part in the ALSPAC study * Able (in the investigator's opinion) and willing to comply with all study requirements * Adequate understanding of verbal and written English Exclusion Criteria: * Pregnant or lactating when they are due to attend for study visit 1 * Less than six months postpartum * Planning to donate blood within two weeks prior to study visit 1 * Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study * Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status For exclusion of MRI component only: * Unsuitable for MRI based on participant screening; the participant may still be included in other parts of the study
Where this trial is running
Oxford, Oxfordshire
- University of Oxford — Oxford, Oxfordshire, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Adam J Lewandowski — Cardiovascular Clinical Research Facility
- Study coordinator: Katie Suriano
- Email: clarity@cardiov.ox.ac.uk
- Phone: 01865 226845
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.