Understanding how metabolism affects blood vessel and immune function in heart disease
Official title: Insights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseases
Funded at Yale University · NIH-11001575 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in our blood vessels and immune cells affect metabolism and inflammation, especially in relation to heart disease like atherosclerosis, to find new ways to help improve heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2021 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $853,373 |
| NIH project number | 5R35HL155988-05 |
| Project ID | NIH-11001575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for or diagnosed with atherosclerosis or other cardiovascular diseases.
✕Less likely to help
Patients with non-atherosclerotic cardiovascular conditions may not receive direct benefits from this research.
What this research studies
This research investigates the molecular mechanisms that regulate metabolism in blood vessels and immune cells, particularly in the context of atherosclerosis, a major cause of cardiovascular disease. It focuses on how endothelial cells, smooth muscle cells, and macrophages respond to metabolic changes and inflammation, which can influence the progression of vascular diseases. The study aims to explore the role of non-coding RNAs, such as microRNAs, in regulating these metabolic responses and their implications for disease outcomes. By understanding these processes, the research seeks to identify potential therapeutic targets for improving cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent atherosclerosis and related cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Suarez, Yajaira — Yale University
- Study coordinator: Suarez, Yajaira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.