Using sildenafil to improve blood vessel health in patients with heart pumps

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of sildenafil, a medication known for its anti-fibrotic properties, on vascular remodeling in patients supported by left ventricular assist devices (LVADs). The research aims to determine if sildenafil can reduce the adverse vascular events that commonly occur in these patients, such as stroke and bleeding. Participants will be randomly assigned to receive either sildenafil or a placebo, and their small blood vessels will be assessed using video capsule endoscopy. The study focuses on understanding how sildenafil impacts vascular health during LVAD support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Over 18 years of age
* Supported by a durable LVAD or planned to undergo placement of a durable LVAD
* Be able to give informed consent

Exclusion Criteria:

* History of pre-existing aortic valve prosthesis or an aortic graft
* Allergy to sildenafil
* Taking any nitric oxide (NO) donor medications
* History of complete carotid occlusion

Where it's running

• Montefiore Medical Center
  The Bronx, New York, United States Recruiting

Study contacts

• Principal investigator: Omar Saeed, MD — Montefiore Medical Center
• Study coordinator: Omar Saeed, MD
• Email: osaeed@montefiore.org
• Phone: 718-920-2626

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.