Condition

Seizures clinical trials and research

• 26Clinical trials
• 67NIH research projects
• 21Countries

Newest Seizures clinical trials

All recruiting trials (26)

• Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's disease

  This trial will test whether the anti-seizure medicine levetiracetam can prevent tonic-clonic seizures and slow cognitive decline in adults over 40 who have Down syndrome and symptomatic Alzheimer's disease.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Granada, Andalusia and 4 other locations · NCT07234695

• Recognizing seizures in the intensive care unit

  This project tests how well NHS neurophysiology scientists, neurologists, intensivists, and ICU nurses can identify seizures from digital video recordings of ICU events.

  Recruiting Nottingham University Hospitals NHS Trust · Nottingham, Nottinghamshire · NCT07136298

• Preventing first seizures with levetiracetam in patients with motor cortex brain metastases

  This test will try giving levetiracetam to adults with motor cortex brain metastases who have never had a seizure to see if it prevents a first seizure compared with not giving the drug.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07130786

• Preventing early seizures after traumatic brain injury

  This randomized study will test whether phenytoin, levetiracetam, or placebo best prevent early seizures in people hospitalized with moderate-to-severe traumatic brain injury.

  Recruiting at 3 sites Phase 4 All India Institute of Medical Sciences, Jodhpur · Chandigarh, Punjab and 2 other locations · NCT07072624

• Wearable device for detecting seizures

  This study tests a new wearable device for detecting seizures in people with epilepsy to see if it works well and can help them feel more comfortable in their daily lives.

  Recruiting at 2 sites University of Massachusetts, Worcester · Worcester, Massachusetts and 1 other locations · NCT06598189

• Registry for patients with thyroid hormone resistance

  This study is collecting information from patients with thyroid hormone resistance to see how their specific gene mutations affect their health and improve diagnosis and treatment.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06566066

• Comparing short and long-term use of levetiracetam for seizures in brain tumor patients

  This study tests whether taking levetiracetam for a shorter time can help brain tumor patients with seizures just as well as the standard longer treatment.

  Recruiting Phase 3 Tata Memorial Centre · Udupi, Karnataka and 1 other locations · NCT06442748

• Investigating brain activity and consciousness in patients with severe brain injuries

  This study is testing a new way to monitor brain activity in patients with severe brain injuries to see if it can help doctors understand their level of consciousness and improve their treatment.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06426615

• Using perampanel to prevent seizures after cardiac arrest

  This study is testing if the medication perampanel can help prevent seizures in patients who have survived a cardiac arrest and are in a coma.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06401707

• Investigating factors that lead to epilepsy after a stroke

  This study is trying to find out what factors might cause epilepsy in people who have had a stroke by comparing them to healthy individuals.

  Recruiting Norwegian University of Science and Technology · Trondheim · NCT05864547

• Using EEG to guide anesthesia for seizures after cardiac arrest

  This study is testing two different ways of using EEG to guide anesthesia in patients who have had a cardiac arrest and are experiencing severe seizures, to see which method works better at controlling those seizures.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05851391

• Using focused ultrasound to reduce seizures in patients with status epilepticus

  This study is testing whether a new ultrasound treatment can help reduce seizures in patients who haven't responded to regular medications.

  Recruiting Yale University · New Haven, Connecticut · NCT05784805

• Understanding how oxygen toxicity affects scuba divers

  This study is testing how different factors like exercise, sleep, and medication affect the risk of oxygen toxicity in scuba divers.

  Recruiting Duke University · Durham, North Carolina · NCT05761756

• Effects of scopolamine on brain activity related to memory in epilepsy patients

  This study is testing if the drug scopolamine can change how well people with epilepsy remember things by looking at their brain activity while they do memory tasks.

  Recruiting Early Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT05594017

• Evaluating Carisbamate for Seizures in Lennox Gastaut Syndrome

  This study is testing if a new medication called carisbamate can help reduce drop seizures in people aged 4 to 55 with Lennox Gastaut Syndrome.

  Recruiting at 32 sites Phase 3 SK Life Science, Inc. · Palo Alto, California and 70 other locations · NCT05219617

• Creation of a database linking EEG recordings with clinical information for epilepsy patients

  This study is creating a database that links brain wave recordings and medical information from epilepsy patients to see if it can help improve treatment and predict seizures better.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT05140265

• Optimizing seizure treatment for children in ambulances

  This study is testing a new way for paramedics to treat seizures in children during ambulance rides to see if it works better than the usual methods.

  Recruiting at 20 sites Phase 3 Stanford University · Tucson, Arizona and 19 other locations · NCT05121324

• Analyzing brain imaging biomarkers in patients with cerebral cavernous malformation-related epilepsy

  This study is trying to see if brain scans can help find signs of iron buildup in people with cerebral cavernous malformation and epilepsy, which could improve how we manage their condition.

  Recruiting at 2 sites Beijing Tiantan Hospital · Beijing, Beijing Municipality and 1 other locations · NCT04076449

• Understanding and treating seizures in newborns

  This study is testing how genetic information can help doctors better understand and treat seizures in newborns during their first month of life.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT03822741

• Observational study of genetic variants in neurodevelopmental disorders

  This study looks at how certain genetic changes affect people with neurodevelopmental disorders like autism and intellectual disabilities to better understand their treatment and related health issues.

  Recruiting Columbia University · New York, New York · NCT03492060

• Investigating epilepsy and its treatment options

  This study is looking to better understand epilepsy and improve treatments for people aged 8 and older who have drug-resistant epilepsy by examining their medical history and conducting tests.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03478852

• Managing seizures in critically ill children using EEG monitoring

  This study looks at how continuous EEG monitoring can help doctors manage seizures in critically ill children and improve their care in the hospital.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT03419260

• Exploring how brain stimulation affects movement intention

  This study is testing how brain stimulation techniques can help people with movement disorders and non-epileptic seizures by looking at how they affect the intention to move.

  Recruiting NYU Langone Health · New York, New York · NCT03233399

• Identifying genetic causes of heart issues in epilepsy patients

  This study is trying to find out if certain genetic factors can help explain why some young adults with epilepsy are at risk for sudden death.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02824822

• Observational study on neonatal seizures

  This study looks at how common seizures are in newborns during their first month of life by using brain scans to see if they have seizures and to find out what might put some babies at higher risk.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT02552511

• Effects of a Ketogenic Diet on Seizures in Children

  This study tests if a ketogenic diet can help children with seizures who don't respond well to regular treatments by looking at how it affects their seizure frequency and medication needs.

  Recruiting University of Florida · Gainesville, Florida · NCT02216500

NIH-funded research (newest 40 of 67)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Pediatric EMS seizures: simpler age-based midazolam dosing

  A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.

  NIH research Stanford University · Stanford, United States · NIH-11617686

• Gene editing therapies to prevent epileptic seizures

  A new gene-editing approach aims to reduce seizures in people with epilepsy by directly modifying a brain gene tied to the condition.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11605225

• Detecting Absence Seizures in Kids at Home with a Mobile Recorder

  A new mobile app helps doctors remotely diagnose and monitor childhood absence epilepsy using guided hyperventilation and video analysis to speed up treatment.

  NIH research Eysz, INC. · Berkeley, UNITED STATES · NIH-11584327

• Seizures and long-term outcomes after childhood stroke

  This project looks at whether early seizures and inflammation after a childhood stroke are linked to later epilepsy and recovery in kids up to 19 years old.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11474008

• Using the brain’s natural connector to detect and prevent seizures

  A study at Case Western Reserve University is exploring whether gently stimulating a natural brain pathway called the corpus callosum can help identify where seizures start and stop them from spreading in people with hard-to-control epilepsy.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11449578

• Disentangling How Inhibitory Brain Cells Shape Seizures in People

  This NIH grant tests how specific brain cells that normally calm the brain influence seizures in adults, using advanced optical methods in living subjects.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11448856

• Defining the brain regions that trigger seizures in epilepsy

  Researchers are studying which parts of the brain cause seizures in people with epilepsy to guide safer, more effective epilepsy surgery.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11447901

• Predicting newborn seizure risk with smart computer tools

  A project to develop a real-time, user-friendly model that uses short brainwave data and basic patient information to predict seizures in newborns at risk of brain injury.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11439839

• Predicting seizure patterns in focal epilepsy patients

  Aims to create personalized models to forecast how often seizures will happen over time in people with focal epilepsy.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11402547

• Investigational WNT-pathway modulators to help people with drug-resistant seizures

  This NIH grant explores new WNT-pathway drugs to help adults with seizures that don’t respond to standard medicines.

  NIH research University of Washington · Seattle, United States · NIH-11395163

• Amygdala-Driven Control of Thalamus: New Avenues for Seizure and Mood Symptoms

  A doctor-scientist team at UCSF is studying how the amygdala can influence thalamic signals to reduce seizures and improve mood and attention problems in epilepsy.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11392349

• Post-stroke seizure mechanisms and treatments in a mouse model

  Researchers are testing new ways to prevent seizures after a stroke using a mouse model and two potential treatments.

  NIH research University of Virginia · Charlottesville, United States · NIH-11381678

• How seizures affect breathing and recovery to prevent SUDEP

  This study looks at how seizures may disrupt breathing and recovery from seizures, with the goal of preventing SUDEP in people with difficult-to-treat epilepsy.

  NIH research University of Iowa · Iowa City, United States · NIH-11353820

• Cerebellum stimulation to stop temporal lobe seizures

  Using targeted stimulation of the cerebellum to try to stop temporal lobe seizures in adults.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11335713

• Brain circuits that help stop absence seizures

  Researchers are mapping and testing specific brain pathways to discover new ways to stop absence seizures for people whose seizures do not respond to medicines.

  NIH research Georgetown University · Washington, United States · NIH-11327286

• How early-life seizures change brain connections

  This research looks at how seizures in infancy can cause lasting changes to nerve-cell connections that may underlie learning, memory, or social difficulties.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11298999

• Seizures after childhood stroke and how they affect recovery

  This project examines whether seizures that happen soon after a child's stroke cause more inflammation and raise the chance of developing epilepsy later on.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11290284

• Understanding how brain circuits control seizures in epilepsy

  This study is looking at how certain brain cells behave during seizures in adults with temporal lobe epilepsy, hoping to find new ways to better control seizures and improve treatment for people living with this condition.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11268781

• Brain circuits that trigger and stop seizures

  Using light-based labeling and control in animal models of temporal lobe epilepsy, researchers hope to find a small group of hippocampal cells that start seizures and stop them to help people with hard-to-control seizures.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11261752

• Simpler, age-based seizure medicine dosing for kids in ambulances

  This project uses simple age-based midazolam doses given by paramedics to stop seizures in children before they reach the emergency room.

  NIH research Stanford University · Stanford, United States · NIH-11261636

• Why fevers can cause seizures in infants and toddlers

  Researchers are looking at how changes in certain brain cells in early childhood make fevers trigger seizures in babies and young children.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11252172

• Investigating how UBE3A affects seizures in a genetic syndrome

  This study is looking at how a protein called UBE3A might cause seizures in people with Duplication 15q syndrome, using fruit flies to see how changes in certain brain cells could be affecting seizure activity, with the hope of finding better treatments for those who struggle with their epilepsy.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11243907

• WNT pathway treatments for preventing and treating drug-resistant seizures

  This work tests medicines that target the WNT signaling pathway to help adults whose seizures do not respond to current anti-seizure drugs.

  NIH research University of Washington · Seattle, United States · NIH-11239953

• How thalamus regions affect seizure spread and memory in epilepsy

  This project looks at how two thalamus areas are involved in seizure spread and memory in people with hard-to-treat temporal lobe epilepsy using direct brain recordings and stimulation.

  NIH research Stanford University · Stanford, United States · NIH-11238899

• Why Tuberous Sclerosis causes seizures and behavioral problems

  Researchers are using new genetic mouse models to learn why people with Tuberous Sclerosis (TSC) develop seizures and related behavioral and learning difficulties.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11237079

• Behavior-based signs to predict seizures and death risk in epilepsy

  Researchers are using AI-driven 3D video analysis of mouse behaviors to find subtle behavior patterns that might signal seizure risk and higher mortality for people with epilepsy.

  NIH research Stanford University · Stanford, United States · NIH-11235874

• How seizures that start in the hippocampus affect the rest of the brain

  Researchers are looking at whether hippocampal seizures reduce brain arousal and slow outer-brain activity in people with temporal lobe epilepsy and whether stimulating arousal centers can help restore awareness.

  NIH research Yale University · New Haven, United States · NIH-11235095

• How a mitochondrial calcium channel affects brain activity and seizures

  This project looks at whether blocking a tiny mitochondrial calcium channel can lower seizures for people with epilepsy who don't respond to current medicines.

  NIH research University of Iowa · Iowa City, United States · NIH-11231708

• ReACT therapy to boost control and reduce catastrophic symptom expectations in children with non-epileptic seizures

  ReACT is a therapy for children and teens with psychogenic non-epileptic seizures designed to help them feel more in control and reduce seizure-like episodes by changing how they interpret symptoms.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11179204

• Optimizing seizure treatment for children in emergency medical services

  This study is looking to make it easier and quicker for paramedics to give the right amount of medicine to kids having seizures, so they can get better care when they need it most.

  NIH research Stanford University · Stanford, United States · NIH-11177281

• Predicting seizure patterns for people with focal epilepsy

  This project builds tools to forecast how often seizures may happen over time for people with focal epilepsy using long-term seizure records.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11169981

• Understanding how brain circuits control seizures in epilepsy

  This study is looking at how certain brain cells behave during seizures in people with temporal lobe epilepsy, with the hope of finding new ways to help those who struggle to control their seizures.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11164717

• Improving Treatment for Neonatal Seizures with Levetiracetam

  This project aims to find the best dose of a medication called Levetiracetam to help babies who have mild to moderate seizures shortly after birth.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11161159

• Exploring how the cerebellum affects seizures in the brain.

  This study is exploring how stimulating certain parts of the brain's cerebellum might help control seizures in people with temporal lobe epilepsy, using animal models to find new ways to improve treatment for those living with this condition.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11160925

• Precise Prediction and Treatment of Seizures After Brain Bleeds

  This project aims to better predict who will have seizures after a brain bleed and tailor seizure prevention meds to improve outcomes for patients.

  NIH research Northwestern University · Chicago, United States · NIH-11159410

• Retraining and Control Therapy (ReACT) for children with functional seizures

  This project explores a mind and body treatment called ReACT to help children and teenagers aged 11-18 who experience functional seizures.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11140399

• Investigating how neuronal activity affects glioma growth

  This study is looking at how brain activity, like seizures, might affect the growth of gliomas, a type of brain tumor, and it aims to find new treatment options for people with this condition by exploring how certain signals in the brain interact with tumor cells.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11140261

• Understanding how early life seizures affect brain connections

  This study is looking at how having seizures early in life can affect brain connections and behavior as animals grow up, with the goal of finding new ways to help people who experience similar challenges.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11109619

• Understanding how seizures affect breathing and consciousness

  This study is looking into why some people with epilepsy experience sudden unexpected death, focusing on how seizures might affect breathing and heart function, and it aims to find new ways to help those at higher risk.

  NIH research University of Iowa · Iowa City, United States · NIH-11079660

• Understanding brain overactivity and seizures in SCN2A-related autism

  This project aims to understand why some children with autism who have changes in their SCN2A gene also experience difficult-to-control seizures.

  NIH research Purdue University · West Lafayette, United States · NIH-11075268

Related topics

Quick answers

How many Seizures clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (16 trials), China (3 trials), Germany (2 trials), Spain (2 trials), India (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Phase 2: 3, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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