Investigating how neuronal activity affects glioma growth
Official title: Targeting Purinergic Signaling to Block the Effects of Seizures on Glioma Progression
Funded at Columbia University Health Sciences · NIH-11140261 · Data updated 2026-11-12
This study is looking at how brain activity, like seizures, might affect the growth of gliomas, a type of brain tumor, and it aims to find new treatment options for people with this condition by exploring how certain signals in the brain interact with tumor cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2024 |
| Project end | March 14, 2028 |
| Funding year | 2025 |
| Award (this year) | $51,501 |
| NIH project number | 5F30CA288006-02 |
| Project ID | NIH-11140261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with gliomas who may experience seizures or other forms of neuronal activity.
✕Less likely to help
Patients with gliomas who do not experience seizures or have other unrelated brain conditions may not benefit from this research.
What this research studies
This research explores the relationship between neuronal activity and the progression of gliomas, a type of brain tumor. It focuses on how seizures and other neuronal signals can influence glioma cells through a specific receptor called P2RX7, which responds to ATP released during neuronal hyperactivity. By using advanced imaging techniques, the study aims to understand the mechanisms behind this interaction and identify potential new treatments for glioma patients. The research will involve both laboratory experiments and analysis of brain tissue samples.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that inhibit glioma progression by targeting purinergic signaling pathways.
How similar studies have gone: While the specific approach of targeting purinergic signaling in gliomas is relatively novel, there is existing evidence that neuronal activity influences tumor progression, suggesting potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Pereira, Brianna — Columbia University Health Sciences
- Study coordinator: Pereira, Brianna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.