Understanding how early life seizures affect brain connections
Tracking the evolution of synaptic dysplasticity after early life seizures
This study is looking at how having seizures early in life can affect brain connections and behavior as animals grow up, with the goal of finding new ways to help people who experience similar challenges.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11109619 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of early life seizures on brain connections and behavior. By studying animal models, the team aims to understand how these seizures disrupt normal brain function and lead to cognitive and social challenges later in life. The researchers will focus on specific brain receptors and pathways that are altered due to these seizures, using advanced techniques to track changes at the level of individual neurons. This approach will help identify potential new treatments for individuals affected by these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals under 21 years old who have experienced seizures in early life and may be facing cognitive or behavioral challenges.
Not a fit: Patients who have not experienced early life seizures or do not exhibit cognitive or behavioral deficits related to such seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for individuals suffering from cognitive and behavioral deficits due to early life seizures.
How similar studies have performed: Previous research has shown promising results in understanding the effects of early life seizures on brain function, indicating that this approach has potential for significant advancements.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jensen, Frances E — University of Pennsylvania
- Study coordinator: Jensen, Frances E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.