Precise Prediction and Treatment of Seizures After Brain Bleeds
Official title: Precise Prediction and Treatment of Seizures After Intracranial Hemorrhage
Funded at Northwestern University · NIH-11159410 · Data updated 2026-11-12
This project aims to better predict who will have seizures after a brain bleed and tailor seizure prevention meds to improve outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $642,980 |
| NIH project number | 5R01NS117608-03 |
| Project ID | NIH-11159410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have suffered an intracranial hemorrhage and are at risk for seizures, with consideration for those facing prophylactic antiseizure therapy.
✕Less likely to help
Patients without intracranial hemorrhage or without seizure risk may not benefit from this research.
What this research studies
People who survive an intracranial hemorrhage often face seizures that worsen recovery and quality of life. The study builds on previous work to predict seizures more accurately and to identify which patients truly benefit from preventive antiseizure medications. By refining prediction methods and treatment decisions, the research seeks to reduce complications and cognitive impact while guiding clinicians on when to use medications like levetiracetam. The goal is to personalize care so that each patient receives the right prevention strategy at the right time.
Why it matters
Potential benefit: If successful, patients could experience fewer seizures, fewer medication-related side effects, and better cognitive and overall outcomes after a brain bleed.
How similar studies have gone: Earlier work has linked specific antiseizure strategies to mixed outcomes, indicating a need for more precise prediction and personalized therapy.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Naidech, Andrew M — Northwestern University
- Study coordinator: Naidech, Andrew M
Related research
Other NIH-funded projects on the same topics.
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Predicting and treating seizures after brain bleeding
This study is looking to help people who have had bleeding in the brain by finding better ways to predict and prevent seizures, so they can get the right treatment and improve their recovery and quality of life.
-
Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
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SATURN MRI ancillary study: statins after intracerebral hemorrhage and brain MRI markers
This study looks at what happens to brain MRI markers and health outcomes when people with a specific type of brain bleed continue or stop taking statins.
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Statin use after brain bleed MRI study in ICH patients (SATURN MRI) Ancillary Study
This project tests whether continuing or stopping statin therapy after an intracerebral hemorrhage affects brain changes seen on MRI and related health outcomes in people with lobar ICH.
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Statin use after brain bleed: SATURN MRI ancillary study
This project tests whether continuing statin medicines after a brain bleed (lobar intracerebral hemorrhage) affects new brain blood vessel findings and long-term health.
-
Pediatric EMS seizures: simpler age-based midazolam dosing
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.