Analyzing brain imaging biomarkers in patients with cerebral cavernous malformation-related epilepsy
Official title: Quantitative Susceptibility Mapping Biomarker, Brain Structure and Connectome Associated With Cerebral Cavernous Malformation Related Epilepsy and Outcome After Surgery
Run by Beijing Tiantan Hospital · NCT04076449 · Data updated 2026-11-12
This study is trying to see if brain scans can help find signs of iron buildup in people with cerebral cavernous malformation and epilepsy, which could improve how we manage their condition.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 2 sites (Beijing, Beijing Municipality and 1 other locations) |
| Status | Recruiting |
| Started | September 3, 2019 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 4, 2019 |
| Trial ID | NCT04076449 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 70 diagnosed with a single cerebral cavernous malformation and no prior treatment of the symptomatic lesion.
✕Probably not a fit
Patients with multiple brain lesions, a history of previous intracranial surgery, or other progressive neurological diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients with cerebral cavernous malformation (CCM) and related epilepsy (CRE). It employs quantitative susceptibility mapping (QSM) to assess iron deposition in the brain, which may contribute to epilepsy. Participants will undergo annual clinical evaluations, including video EEG recordings and MRI studies, over a five-year follow-up period. The study aims to identify biomarkers that predict the risk of CRE and improve management strategies for patients with CCM.
Why it matters
Potential benefit: If successful, this study could lead to better management strategies and improved outcomes for patients with cerebral cavernous malformation-related epilepsy.
How similar studies have gone: While the approach of using quantitative susceptibility mapping is innovative, similar studies have shown promise in understanding brain conditions, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * (1) 18 to 70 years of age * (2) Diagnosed with a single cerebral cavernous malformation * (3) No prior treatment of the symptomatic lesion Exclusion Criteria: * (1) Associated with brain lesions and/or tumors other than CCM * (2) History of previous intracranial surgery * (3) Prior brain irradiation * (4) Contraindication or unwilling or unable to undergo research MRI studies * (5) Pregnant or breastfeeding women * (6) Persons unable or unlikely to return for follow-up visits * (7) Dementia or other progressive neurological disease
Where it's running
-
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China Recruiting -
Peking University International Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Li Ma, MD, PhD — Beijing Tiantan Hospital
- Study coordinator: Li Ma, MD, PhD
- Email: marygl@hotmail.com
- Phone: 86-010-59978317
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.