Exploring how the cerebellum affects seizures in the brain.
Official title: Hippobellum: Cerebellar influence on the hippocampus and temporal lobe seizures
Funded at University of Minnesota · NIH-11160925 · Data updated 2026-11-12
This study is exploring how stimulating certain parts of the brain's cerebellum might help control seizures in people with temporal lobe epilepsy, using animal models to find new ways to improve treatment for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2020 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $593,514 |
| NIH project number | 2R01NS112518-06 |
| Project ID | NIH-11160925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with temporal lobe epilepsy who are 21 years or older.
✕Less likely to help
Patients with other types of epilepsy or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of the cerebellum in controlling seizures, particularly focusing on temporal lobe epilepsy. By using electrical stimulation and optogenetic techniques, the study aims to understand how stimulating specific areas of the cerebellum can inhibit seizures in the hippocampus. The research involves animal models to determine the effectiveness of these stimulation methods and their potential for improving seizure control. The findings could lead to new treatment strategies for patients with epilepsy.
Why it matters
Potential benefit: If successful, this research could provide new, effective treatment options for patients suffering from epilepsy.
How similar studies have gone: Previous research has shown promising results in using cerebellar stimulation for seizure control, indicating potential for success in this approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Krook-Magnuson, Esther — University of Minnesota
- Study coordinator: Krook-Magnuson, Esther
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.