Condition

Acute Brain Injury clinical trials and research

• 10Clinical trials
• 16NIH research projects
• 10Countries

Newest Acute Brain Injury clinical trials

All recruiting trials (10)

• Brain monitoring during ventilator therapy in critically ill patients

  This study tests how lung-directed ventilator adjustments affect brain activity and blood flow in adults with acute brain injury who need mechanical ventilation.

  Recruiting Shengli Oilfield Hospital · Dongying, Shandong · NCT07716787

• Neutral fluid balance in adults with traumatic brain injury (LIMIT-TBI)

  This study tests whether keeping daily fluid balance around zero (within 500 mL) for the first 5 days in the ICU is feasible and safe for adults with traumatic brain injury.

  Recruiting at 3 sites Phase 2 Erasme University Hospital · Brussels and 2 other locations · NCT07625995

• Portable MRI for kids with hypoxic brain injury

  This study tests whether a bedside, low-field portable MRI can accurately detect hypoxic-ischemic brain injuries in children compared with standard imaging.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT07577336

• Early physical mobilisation for adults with moderate to severe acquired brain injury in neuro-ICUs

  This project sees if the amount and intensity of early physical mobilisation for adults with moderate to severe acute brain injury in Scandinavian neuro-ICUs relates to safety and physiological responses.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen and 1 other locations · NCT07548580

• CSF lactate and other biomarkers in patients with an external ventricular drain after acute brain injury

  This project will test whether changes in cerebrospinal fluid lactate and other blood/CSF biomarkers can help detect ventriculostomy-associated infection in adults with acute brain injury who have an external ventricular drain.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen · NCT07380477

• Lung and brain ultrasound to guide PEEP in adults with ARDS and acute brain injury

  This trial will test whether combining lung and transcranial ultrasound helps doctors choose the best PEEP level for adults on a ventilator with ARDS and acute brain injury.

  Recruiting George Papanicolaou Hospital · Thessaloniki · NCT07248995

• Preventing early ventilator infections after severe brain injury

  This will test whether giving a single dose of the antibiotic ceftriaxone soon after starting mechanical ventilation can prevent lung infections and help adults with severe acute brain injury survive.

  Recruiting at 6 sites Phase 3 The George Institute · Canberra, Australian Capital Territory and 28 other locations · NCT06819592

• Detecting brain injuries in children on ECMO using portable MRI

  This study is testing a portable MRI to see if it can help find brain injuries in children on ECMO support more quickly and accurately.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT06469801

• Investigating brain activity and consciousness in patients with severe brain injuries

  This study is testing a new way to monitor brain activity in patients with severe brain injuries to see if it can help doctors understand their level of consciousness and improve their treatment.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06426615

• Assessing readiness for extubation in brain-injured patients

  This study is testing a new way to see if brain-injured patients are ready to be taken off a breathing machine to help them recover better and avoid complications.

  Recruiting at 14 sites University Hospital, Clermont-Ferrand · Angers and 20 other locations · NCT04080440

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Sleep patterns predicting recovery after acute brain injury

  Researchers will look at brain sleep signals to see if certain sleep patterns can forecast when patients who are unconscious after a brain injury may start to wake up and recover.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11458485

• Brain cell ion balance and swelling after sudden brain injury

  They are looking at how changes in ion levels and cell size after a sudden brain injury cause swelling or shrinkage for people with acquired brain injuries, including newborns.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11324023

• EEG tools to predict recovery after sudden brain injury

  This project will use computer-based EEG tools to help doctors predict recovery and seizure risk for people hospitalized with sudden (acute) brain injuries.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11243554

• Using EEG to guide seizure medicines after stroke or head injury

  This project looks at whether using bedside EEG brain monitoring to guide anti-seizure medicines for people with recent stroke or traumatic brain injury can prevent harmful brain activity while cutting down medicine side effects.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11235864

• Understanding Brain Injury During ECMO Treatment

  This research looks at why some people develop brain injury when they receive life-saving ECMO support for severe heart and lung failure.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11163474

• Helping patients with acute brain injuries and their caregivers build resilience together

  This study is for patients who have had a brain injury, like a stroke, and their caregivers, and it offers a friendly program called 'Recovering Together' to help them cope with stress and support each other while they heal in the hospital.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11090444

• Understanding outcomes and care needs after severe brain injuries

  This study is looking at how people who have had serious brain injuries, like strokes or heart attacks, are doing in their final weeks of life and how we can make their care better, while also understanding how this affects their family members who are helping them.

  NIH research University of Washington · Seattle, United States · NIH-11085958

• Understanding how brain injuries affect neuron function and swelling

  This study looks at how sudden brain injuries affect the balance of important minerals in brain cells and how this can lead to swelling, especially in babies and young children, with the goal of finding better ways to treat these injuries.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11082220

• Monitoring brain activity and health in patients with severe brain injuries

  This study is testing a new device called the NeuroProbe that will help doctors keep a closer eye on patients with serious brain injuries by combining several monitoring tools into one, making it easier and safer for you during treatment.

  NIH research Yale University · New Haven, United States · NIH-11067148

• Support for caregivers of patients with severe brain injuries

  This study is creating a supportive program to help family caregivers of patients with serious brain injuries manage their stress and emotions through mindfulness and coping techniques, making sure it fits their specific needs.

  NIH research University of Washington · Seattle, United States · NIH-11004617

• Improving predictions for outcomes in patients with acute brain injuries

  This study is looking to improve how doctors predict recovery for patients with serious brain injuries by using advanced technology to analyze brain wave patterns, helping to identify those at risk for seizures and long-term epilepsy, so they can provide better care.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11002008

• Comparing EEG-guided treatments for seizures in patients with acute brain injuries

  This study is looking at how well EEG-guided treatments can help reduce seizures in people who have had serious brain injuries, like strokes or trauma, to improve their recovery and overall health.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10993209

• Investigating brain injury risks during ECMO treatment

  This study is looking at how changes in carbon dioxide levels during a special heart and lung treatment called ECMO might affect brain health, so we can better understand and protect patients who might be at risk for brain injury during their care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10953908

• Monitoring brain conditions using a single device for acute injuries

  This study is testing a new device called the NeuroProbe that will help doctors keep a closer eye on brain injuries by measuring important things like pressure and oxygen levels in one small, easy-to-use tool, making it safer and simpler for patients.

  NIH research Yale University · New Haven, United States · NIH-10920380

• Investigating blood biomarkers and risk factors for brain injury in Ugandan children

  This study is looking at how serious brain injuries, like those from cerebral malaria and trauma, impact kids' thinking skills, and it aims to find certain blood markers that can help predict if children aged 5 to 15 might have problems with their brain function, especially in places where these injuries are more commo

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10682592

• Investigating the role of microRNA210 in brain inflammation after ischemic stroke

  This study is looking at how a tiny molecule called microRNA210 affects inflammation in the brain after a stroke, with the goal of finding new ways to help stroke patients recover better.

  NIH research Loma Linda University · Loma Linda, UNITED STATES · NIH-10579511

Related topics

Quick answers

How many Acute Brain Injury clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (2 trials), Belgium (2 trials), Denmark (2 trials), France (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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