Using perampanel to prevent seizures after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized placebo-controlled clinical trial aims to evaluate the safety and feasibility of using perampanel for preventing post-cardiac arrest status epilepticus (PCARSE) in patients who have experienced a non-traumatic cardiac arrest. The study will enroll comatose patients who have achieved return of spontaneous circulation within 45 minutes of arrest and will randomize them to receive either perampanel or a placebo after admission to the intensive care unit. The primary outcome will focus on the incidence of severe adverse events, while secondary endpoints will assess seizure incidence, frequency, and time to seizure control.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years old
* Non-traumatic, out-of-hospital cardiac arrest
* Comatose on admission - defined as not following commands
* Return of spontaneous circulation (ROSC) within less than 45 minutes from the time of cardiac arrest (defined as the time of 911 or EMS (emergency medical services) witnessed arrest)
* Admission to the intensive care unit at Zuckerberg San Francisco General Hospital

Exclusion Criteria:

* Acute cerebral hemorrhage or infarction
* Pregnancy
* Prisoner
* Severe kidney function impairment with creatinine clearance inferior to 30 ml/min
* Severe liver impairment with liver function tests five times above the upper limit of normal
* Electrographic or electroclinical seizures diagnosis using American Clinical Neurophysiology criteria confirmed by an epileptologist after cardiac arrest

Where it's running

• Zuckerberg San Francisco General Hospital
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Edilberto Amorim, MD — University of California, San Francisco
• Study coordinator: Edilberto Amorim, MD
• Email: prosperstudy@ucsf.edu
• Phone: 628-206-3203

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.