Optimizing seizure treatment for children in emergency medical services
Official title: Pediatric Dose Optimization for Seizures in EMS (PediDOSE)
Funded at Stanford University · NIH-11177281 · Data updated 2026-11-12
This study is looking to make it easier and quicker for paramedics to give the right amount of medicine to kids having seizures, so they can get better care when they need it most.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $152,474 |
| NIH project number | 3U01NS114042-04S1 |
| Project ID | NIH-11177281 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who experience seizures and require emergency medical intervention.
✕Less likely to help
Patients who do not experience seizures or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research focuses on improving the treatment of seizures in children by emergency medical services (EMS). It aims to address the common issue of under-dosing and delays in administering anti-seizure medication, specifically midazolam. The study will implement a standardized, age-based dosing method to simplify the process for paramedics, making it faster and more effective in treating pediatric seizures. By conducting a large trial across 20 EMS systems, the research seeks to enhance the effectiveness and safety of seizure management in children.
Why it matters
Potential benefit: If successful, this research could lead to more effective and timely treatment of seizures in children, reducing the risk of complications such as brain damage.
How similar studies have gone: Previous research has shown that standardized dosing approaches can improve treatment outcomes in emergency settings, suggesting a promising potential for this method.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Shah, Manish Ishwar — Stanford University
- Study coordinator: Shah, Manish Ishwar
Related research
Other NIH-funded projects on the same topics.
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Pediatric EMS seizures: simpler age-based midazolam dosing
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
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Gene editing therapies to prevent epileptic seizures
A new gene-editing approach aims to reduce seizures in people with epilepsy by directly modifying a brain gene tied to the condition.
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Detecting Absence Seizures in Kids at Home with a Mobile Recorder
A new mobile app helps doctors remotely diagnose and monitor childhood absence epilepsy using guided hyperventilation and video analysis to speed up treatment.
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Seizures and long-term outcomes after childhood stroke
This project looks at whether early seizures and inflammation after a childhood stroke are linked to later epilepsy and recovery in kids up to 19 years old.
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Using the brain’s natural connector to detect and prevent seizures
A study at Case Western Reserve University is exploring whether gently stimulating a natural brain pathway called the corpus callosum can help identify where seizures start and stop them from spreading in people with hard-to-control epilepsy.
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Disentangling How Inhibitory Brain Cells Shape Seizures in People
This NIH grant tests how specific brain cells that normally calm the brain influence seizures in adults, using advanced optical methods in living subjects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.