Seizures and long-term outcomes after childhood stroke
Official title: Seizures and Children's Outcomes after Stroke (SCOUTS)
Funded at University of California, San Francisco · NIH-11474008 · Data updated 2026-11-12
This project looks at whether early seizures and inflammation after a childhood stroke are linked to later epilepsy and recovery in kids up to 19 years old.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $31,764 |
| NIH project number | 3R01NS119896-05S1 |
| Project ID | NIH-11474008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who had an ischemic stroke between 28 days and 19 years of age—especially those who had seizures within one week of the stroke—are the ideal candidates for this research.
✕Less likely to help
People without a prior childhood ischemic stroke, adults whose stroke occurred outside the age range, or anyone seeking immediate treatment rather than contributing samples or data would not benefit directly from this grant.
What this research studies
You would be part of work using information and banked blood from children who had an ischemic stroke to understand why some develop epilepsy. Researchers will analyze inflammatory signals in stored blood samples and review brain imaging to see if where the stroke happened or early seizures predict later seizures. They will use one group of children to find possible links and a second independent group to confirm those findings. The goal is to combine biological markers and imaging to improve understanding of post-stroke epilepsy risk.
Why it matters
Potential benefit: If successful, this work could help identify children at higher risk for epilepsy so doctors can watch more closely or consider preventive strategies.
How similar studies have gone: Prior animal studies and earlier clinical observations link inflammation and stroke location to later epilepsy, but using two pediatric stroke cohorts with banked blood for discovery and validation is a relatively new and more comprehensive approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Fox, Christine K. — University of California, San Francisco
- Study coordinator: Fox, Christine K.
Related research
Other NIH-funded projects on the same topics.
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Post-stroke seizure mechanisms and treatments in a mouse model
Researchers are testing new ways to prevent seizures after a stroke using a mouse model and two potential treatments.
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Seizures after childhood stroke and how they affect recovery
This project examines whether seizures that happen soon after a child's stroke cause more inflammation and raise the chance of developing epilepsy later on.
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Understanding seizures and outcomes in children after a stroke
This study is looking at how seizures that happen soon after a stroke in kids might lead to long-term epilepsy and learning difficulties, and it’s for children aged 28 days to 19 years who have had a stroke.
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This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
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Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.