Seizures and long-term outcomes after childhood stroke
Seizures and Children's Outcomes after Stroke (SCOUTS)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11474008
This project looks at whether early seizures and inflammation after a childhood stroke are linked to later epilepsy and recovery in kids up to 19 years old.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11474008 on ClinicalTrials.gov |
What this research studies
You would be part of work using information and banked blood from children who had an ischemic stroke to understand why some develop epilepsy. Researchers will analyze inflammatory signals in stored blood samples and review brain imaging to see if where the stroke happened or early seizures predict later seizures. They will use one group of children to find possible links and a second independent group to confirm those findings. The goal is to combine biological markers and imaging to improve understanding of post-stroke epilepsy risk.
Who could benefit from this research
Good fit: Children who had an ischemic stroke between 28 days and 19 years of age—especially those who had seizures within one week of the stroke—are the ideal candidates for this research.
Not a fit: People without a prior childhood ischemic stroke, adults whose stroke occurred outside the age range, or anyone seeking immediate treatment rather than contributing samples or data would not benefit directly from this grant.
Why it matters
Potential benefit: If successful, this work could help identify children at higher risk for epilepsy so doctors can watch more closely or consider preventive strategies.
How similar studies have performed: Prior animal studies and earlier clinical observations link inflammation and stroke location to later epilepsy, but using two pediatric stroke cohorts with banked blood for discovery and validation is a relatively new and more comprehensive approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOX, CHRISTINE K. — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FOX, CHRISTINE K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury