Pediatric EMS seizures: simpler age-based midazolam dosing
Official title: Pediatric Dose Optimization for Seizures in EMS (PediDOSE)
Funded at Stanford University · NIH-11617686 · Data updated 2026-11-12
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2021 |
| Project end | November 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $101,649 |
| NIH project number | 3U01NS114042-05S1 |
| Project ID | NIH-11617686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years experiencing seizures and treated by EMS in participating systems.
✕Less likely to help
Children outside the 0-11 age range or not experiencing EMS-treated seizures may not benefit.
What this research studies
This project aims to give paramedics a straightforward, age-based dosing rule for midazolam to treat seizures in children, hoping to reduce delays and under-dosing. The study will compare standardized dosing to current weight-based methods across 20 EMS systems. If successful, it could make emergency seizure care faster and safer for kids under 12. The research will monitor seizure cessation, breathing safety, and any adverse events to ensure no new risks are introduced.
Why it matters
Potential benefit: If successful, children with seizures could receive faster, more reliable treatment in the field, potentially reducing brain injury risk.
How similar studies have gone: Previous work suggests dosing consistency improves timeliness; this trial tests age-based dosing in a real-world setting.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Shah, Manish Ishwar — Stanford University
- Study coordinator: Shah, Manish Ishwar
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.