Optimizing seizure treatment for children in ambulances

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Pediatric Dose Optimization for Seizures in Emergency Medical Services (PediDOSE) study aims to enhance the treatment of seizures in children by paramedics during ambulance transport. It addresses the common issue of under-dosing and delayed medication delivery, which can lead to continued seizures upon arrival at emergency departments. The study compares a standardized seizure protocol using muscular injection or nasal spray against conventional methods to determine effectiveness and safety in pediatric patients. This research is crucial as most existing studies have focused on adults, highlighting the need for tailored approaches for children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Witnessed by the paramedic to be actively seizing, regardless of seizure type or duration; AND
* Under the care of a paramedic; AND
* Transported by an EMS agency participating in the study

Exclusion Criteria:

* A prior history of a benzodiazepine allergy; OR
* Known or presumed pregnancy; OR
* Severe growth restriction based on the paramedic's subjective assessment

Where it's running

• University of Arizona
  Tucson, Arizona, United States Recruiting
• Children's Hospital of Los Angeles
  Los Angeles, California, United States Recruiting
• University of California, Davis
  Sacramento, California, United States Recruiting
• University of California, San Francisco
  San Francisco, California, United States Recruiting
• University of Colorado
  Aurora, Colorado, United States Recruiting
• Children's National Hospital
  Washington D.C., District of Columbia, United States Recruiting

Study contacts

• Principal investigator: Manish I Shah, MD, MS — Stanford University
• Study coordinator: Manish I Shah, MD, MS
• Email: mshah5@stanford.edu
• Phone: 650-723-3319

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.