Seizures after childhood stroke and how they affect recovery
Seizures and Children's Outcomes after Stroke (SCOUTS)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11290284
This project examines whether seizures that happen soon after a child's stroke cause more inflammation and raise the chance of developing epilepsy later on.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11290284 on ClinicalTrials.gov |
What this research studies
If your child had an ischemic stroke between 28 days and 19 years of age, researchers will use clinical records, brain imaging, and banked blood samples already collected in two large pediatric stroke groups to learn more about seizures after stroke. Children who had seizures within one week of the stroke will be compared with those who did not to study inflammatory signals and the location of the brain injury. One cohort will be used to find patterns and a second independent cohort will be used to confirm them. The team will link these findings to whether children went on to develop epilepsy over time.
Who could benefit from this research
Good fit: Children aged 28 days to 19 years at the time of ischemic stroke who were enrolled in the VIPS I or VIPS II pediatric stroke cohorts, especially those who had acute seizures within one week of their stroke.
Not a fit: Children whose strokes occurred outside the specified age range, who were not part of the VIPS cohorts, or who lack available blood samples or imaging data are unlikely to be included or to directly benefit from this grant's analyses.
Why it matters
Potential benefit: If successful, this work could point to blood markers or brain features that help predict or prevent epilepsy after childhood stroke, improving long-term outcomes and quality of life.
How similar studies have performed: Animal experiments and prior clinical work link post-stroke inflammation and injury location to epilepsy risk, but using blood biomarkers plus imaging across two pediatric cohorts for discovery and validation is a newer, translational approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOX, CHRISTINE K. — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FOX, CHRISTINE K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury