Using EEG to guide anesthesia for seizures after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the safety and feasibility of two different EEG-guided anesthesia approaches for treating refractory status epilepticus in patients who have survived cardiac arrest. Participants will be randomly assigned to receive either burst suppression or seizure suppression anesthesia for 24 hours, with the possibility of repeating the intervention if seizures recur. The study aims to determine which EEG target is more effective in controlling seizures following cardiac arrest. The trial will involve continuous EEG monitoring to confirm the diagnosis of post-cardiac arrest refractory status epilepticus.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years old
2. Non-traumatic, out-of-hospital cardiac arrest
3. Comatose on admission - defined as not following commands
4. Return of spontaneous circulation (ROSC) within less than 45 minutes
5. Admission to the intensive care unit
6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous

EEG monitoring within 7 days from ROSC

Exclusion Criteria:

1. Acute cerebral hemorrhage or infarction
2. Pregnancy
3. Prisoners

Where it's running

• Zuckerberg San Francisco General Hospital
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Edilberto Amorim, MD — Assistant Professor of Neurology
• Study coordinator: Edilberto Amorim, MD
• Email: restorestudy@ucsf.edu
• Phone: 628-206-3203

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.