Using EEG to guide anesthesia for seizures after cardiac arrest
buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest (RESTORE)
This study is testing two different ways of using EEG to guide anesthesia in patients who have had a cardiac arrest and are experiencing severe seizures, to see which method works better at controlling those seizures.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT05851391 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the safety and feasibility of two different EEG-guided anesthesia approaches for treating refractory status epilepticus in patients who have survived cardiac arrest. Participants will be randomly assigned to receive either burst suppression or seizure suppression anesthesia for 24 hours, with the possibility of repeating the intervention if seizures recur. The study aims to determine which EEG target is more effective in controlling seizures following cardiac arrest. The trial will involve continuous EEG monitoring to confirm the diagnosis of post-cardiac arrest refractory status epilepticus.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have experienced a non-traumatic out-of-hospital cardiac arrest and are comatose upon admission.
Not a fit: Patients with acute cerebral hemorrhage or infarction, pregnant individuals, and prisoners will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve seizure control and outcomes for patients recovering from cardiac arrest.
How similar studies have performed: While the use of EEG-guided anesthesia is established, this specific comparison of burst suppression versus seizure suppression in post-cardiac arrest patients is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥18 years old 2. Non-traumatic, out-of-hospital cardiac arrest 3. Comatose on admission - defined as not following commands 4. Return of spontaneous circulation (ROSC) within less than 45 minutes 5. Admission to the intensive care unit 6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous EEG monitoring within 7 days from ROSC Exclusion Criteria: 1. Acute cerebral hemorrhage or infarction 2. Pregnancy 3. Prisoners
Where this trial is running
San Francisco, California
- Zuckerberg San Francisco General Hospital — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Edilberto Amorim, MD — Assistant Professor of Neurology
- Study coordinator: Edilberto Amorim, MD
- Email: restorestudy@ucsf.edu
- Phone: 628-206-3203
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.