Condition

Brain Metastases, Adult clinical trials and research

• 23Clinical trials
• 11Countries

Newest Brain Metastases, Adult clinical trials

All recruiting trials (23)

• Tarlatamab for Small Cell Lung Cancer with Brain Metastases

  This phase II study tests whether tarlatamab can help adults with small cell lung cancer that has spread to the brain, by treating both systemic disease and brain tumors.

  Recruiting at 3 sites Phase 2 Maastricht University Medical Center · Amsterdam and 3 other locations · NCT07402343

• AI-assisted diagnosis for malignant brain tumors

  This project will test an AI system that uses routine preoperative MRI scans to automatically segment and classify malignant brain tumors in adults to help guide diagnosis and care.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT07198256

• Same-day stereotactic radiation with reduced planning margins for growing or changing brain metastases

  This trial will try to see if doing MRI planning and stereotactic radiation on the same day, with either a 0 mm or 1 mm treatment margin, helps adults with growing or unstable brain metastases stay on target and reduce side effects.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07132190

• Preventing first seizures with levetiracetam in patients with motor cortex brain metastases

  This test will try giving levetiracetam to adults with motor cortex brain metastases who have never had a seizure to see if it prevents a first seizure compared with not giving the drug.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT07130786

• Avoiding brain radiation when systemic therapy already targets brain metastases

  This pilot trial tests whether patients with brain metastases who respond to systemic therapy can skip brain radiation.

  Recruiting Phase 2 University of Vermont Medical Center · Burlington, Vermont · NCT06974370

• Using ex vivo pharmacoscopy to guide treatment for brain metastases

  This project will test whether pharmacoscopy, a lab test that screens a patient's tumor cells against many drugs, can help pick effective treatments for adults having surgery for brain metastases.

  Recruiting at 2 sites Phase 2 University of Zurich · Basel and 2 other locations · NCT06620380

• DE-iPTV radiotherapy for breast cancer that has spread to the brain in patients not eligible for SRS

  This trial tests a dose-escalated internal PTV radiotherapy approach (DE-iPTV) for adults with breast cancer brain metastases who can’t have stereotactic radiotherapy, to see if it can be delivered safely and whether it improves quality of life.

  Recruiting at 2 sites Imperial College London · London, London and 1 other locations · NCT06611306

• Investigating genetic similarities between primary colorectal tumors and their brain metastases

  This study is looking at the genetic similarities between original colorectal cancer tumors and their brain metastases to see how closely they match in terms of important gene mutations.

  Recruiting Blokhin's Russian Cancer Research Center · Moscow, Moscow · NCT06449989

• Combining sacituzumab govitecan and bevacizumab for treating brain metastases in lung cancer

  This study is testing if a combination of two drugs, sacituzumab govitecan and bevacizumab, can help shrink brain tumors in patients with lung cancer who haven't responded to other treatments.

  Recruiting at 3 sites Phase 2 Maastricht University Medical Center · Amsterdam and 2 other locations · NCT06401824

• Intensive multi-disciplinary care for patients with brain metastases

  This study is testing if a team-based approach to care for patients with newly diagnosed brain metastases can help them feel better and understand their condition more clearly compared to standard care.

  Recruiting University of Vermont Medical Center · Burlington, Vermont · NCT06280300

• Feasibility of advanced stereotactic radiotherapy for brain metastases

  This study is testing a new type of precise radiation treatment for patients with brain metastases to see if it can control tumors better and improve their quality of life compared to standard methods.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06231186

• Evaluating brain metastasis treatment using PET imaging

  This study is testing if a special type of brain scan can help doctors see how well treatment is working for patients with brain tumors caused by cancer.

  Recruiting Phase 1 Baptist Health South Florida · Miami, Florida · NCT06048094

• Testing NEO212 for treating certain brain tumors and metastases

  This study is testing a new treatment called NEO212 for people with certain types of brain tumors to see if it is safe and effective when combined with standard treatments.

  Recruiting at 8 sites Phase 1/2 Neonc Technologies, Inc. · Beverly Hills, California and 7 other locations · NCT06047379

• Using silibinin to prevent brain metastasis recurrence in lung and breast cancer patients

  This study is testing if a medication called silibinin can help prevent brain cancer from coming back in patients who have had surgery for lung or breast cancer.

  Recruiting at 2 sites A.O.U. Città della Salute e della Scienza · Genova and 5 other locations · NCT05689619

• New MRI technique to assess brain tumors after treatment

  This study is testing a new MRI method to see if it can tell the difference between real tumor growth and changes caused by treatment in people with brain tumors.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT05559853

• Comparing preoperative and postoperative hypofractionated radiosurgery for large brain metastases

  This study tests whether giving targeted radiation before or after surgery helps people with large brain tumors do better and have fewer side effects.

  Recruiting at 8 sites Istituto Clinico Humanitas · Brescia, Brescia and 8 other locations · NCT05545007

• Collection of blood samples from adults with brain tumors

  This study is collecting blood samples from adults with brain tumors to see if certain markers in the blood can help improve treatment outcomes after radiation therapy.

  Recruiting Duke University · Durham, North Carolina · NCT05480644

• Stereotactic radiosurgery for lung cancer that has spread to the brain

  This study is testing if a targeted radiation treatment can help people with small cell lung cancer that has spread to their brain feel better and improve their outcomes.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05419076

• Comparing preoperative and postoperative radiation for brain metastases

  This study tests if giving radiation before surgery for brain metastases can lower the chance of cancer spreading in the brain compared to giving it after surgery.

  Recruiting at 9 sites Kantonsspital Aarau · Innsbruck and 9 other locations · NCT05124236

• Neurocognitive assessment in patients with brain oligometastases receiving targeted radiotherapy

  This study is testing if a new type of targeted radiation therapy can help people with brain oligometastases keep their thinking skills better than the usual whole-brain radiation.

  Recruiting at 2 sites Chang Gung Memorial Hospital · Taoyuan and 1 other locations · NCT04805255

• Using 18F-Fluciclovine to Monitor Brain Metastases After Radiation Therapy

  This study is testing a new imaging agent called 18F-fluciclovine to see if it can help track how well radiation therapy is working for people with large brain metastases.

  Recruiting Phase 1 Baptist Health South Florida · Miami, Florida · NCT04689048

• Cognitive-sparing radiosurgery for brain metastases

  This study is testing a new way to use targeted radiation for patients with brain tumors to see if it can help protect their thinking skills while treating the cancer.

  Recruiting Phase 2 University of California, San Diego · San Diego, California · NCT04343157

• Using brain imaging to predict treatment response in patients with brain metastases

  This study is testing if brain scans can help predict how well patients with brain metastases will respond to radiation treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT04197297

Related topics

Quick answers

How many Brain Metastases, Adult clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (11 trials), Netherlands (2 trials), Italy (2 trials), Switzerland (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 9, Phase 1: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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