Condition

Intellectual Disability clinical trials and research

• 23Clinical trials
• 26NIH research projects
• 1New in 30 days
• 9Countries

Newest Intellectual Disability clinical trials

All recruiting trials (23)

• Leopard: using multi-omics to boost genetic diagnosis for neurodevelopmental disorders

  This study tests a multi-omics approach to find genetic explanations for neurodevelopmental disorders in people with moderate-to-severe intellectual disability.

  Recruiting Istituto Giannina Gaslini · Genova · NCT07884227

• Regulating Together for Emotion Dysregulation in ASD and Intellectual Disability (group therapy)

  This study tests a group therapy program for kids with autism and co-occurring intellectual disability to help them manage irritability and aggression, with sessions for both children and their caregivers.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT07624448

• Digital games to improve visual memory and thinking skills in young adults with intellectual disability

  This trial will test whether twice-weekly MentalUP digital game sessions help 18–35-year-olds with mild to moderate intellectual disability improve visual memory and cognitive skills.

  Recruiting Koç University · Istanbul, Türkiye · NCT07476092

• Using preferred communication tools to reduce challenging behavior

  This project will test whether using a person's favored communication tool (for example a touch talker or picture cards) helps keep behavior improvements and prevents relapse in people with intellectual or developmental disabilities who have little or no verbal speech.

  Recruiting at 2 sites University of Georgia · Athens, Georgia and 1 other locations · NCT07278544

• Deutetrabenazine for Tardive Dyskinesia in IDD

  This study tests whether deutetrabenazine helps reduce tardive dyskinesia in people with intellectual and developmental disabilities who have not previously received this treatment.

  Recruiting Phase 4 University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT06997198

• Theta Burst Stimulation for Emotion Regulation in Autism With Minimal Verbal Ability or Intellectual Disability

  This trial tests whether intermittent theta burst stimulation to the left prefrontal cortex can help improve emotion regulation in people with autism who are minimally verbal or have an intellectual disability.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT06974838

• Hands-on cooking classes to help young adults with intellectual disabilities keep weight off

  This program will test whether adding in-person cooking classes to a weight-loss plan helps young adults (18–35) with mild-to-moderate intellectual disabilities lose weight and keep it off.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06961591

• Inclusive physical activity program for adults with intellectual disabilities

  This study is testing a new fitness program for adults with intellectual disabilities to see if it helps them be more active and feel better over 16 weeks.

  Recruiting University of North Carolina, Chapel Hill · Fayetteville, Arkansas and 1 other locations · NCT06740162

• Creating a tool to help caregivers identify eye problems in adults with intellectual disabilities

  This study is testing a new tool to help caregivers spot eye problems in adults with intellectual disabilities to improve their health care.

  Recruiting at 2 sites National Taiwan University Hospital · New Taipei City and 1 other locations · NCT06737627

• Registry for patients with thyroid hormone resistance

  This study is collecting information from patients with thyroid hormone resistance to see how their specific gene mutations affect their health and improve diagnosis and treatment.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06566066

• Observational study on MEHMO syndrome and related conditions

  This study follows people with MEHMO syndrome and related disorders to see how the conditions develop over time and to find better ways to diagnose and manage them.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06019182

• Home-based parenting support for parents with intellectual disabilities

  This study tests a special parenting program for parents with intellectual disabilities to see if it helps them improve their skills and keep their children safe from neglect.

  Recruiting at 5 sites Örebro University, Sweden · Enköping and 4 other locations · NCT05935722

• Using prescribed physical activity to improve health in people with disabilities

  This study is testing whether a program that prescribes specific physical activities can help children and young people with disabilities, like autism and intellectual disabilities, improve their health and be more active.

  Recruiting Region Skane · Malmö · NCT05867940

• Analyzing genetic markers in patients with intellectual disabilities

  This study is trying to learn more about the genetic causes of intellectual disabilities, like Down Syndrome, by looking at blood and skin samples from patients to find better ways to diagnose and treat these conditions.

  Recruiting Institut Jerome Lejeune · Paris · NCT05767203

• Using Metformin to Manage Weight Gain from Antipsychotics in Adults with Intellectual Disabilities

  This study tests if Metformin can help adults with intellectual disabilities who are gaining weight from antipsychotic medications lose weight and improve their health.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05744479

• Using heart rate to improve care for non-verbal patients

  This study is testing if using heart rate data can help caregivers provide better and more comfortable care for non-verbal patients, like those with autism.

  Recruiting at 2 sites University of Oslo · Oslo and 1 other locations · NCT05738278

• Understanding pain responses in individuals with intellectual disability

  This study tests how people with intellectual disabilities experience pain compared to healthy individuals by looking at their brain activity and physical reactions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05473429

• Understanding mental health crises in youth with intellectual disabilities

  This study looks at young people with intellectual disabilities who come to the emergency room for mental health crises to see what factors might put them at risk and how to improve their care.

  Recruiting Rady Pediatric Genomics & Systems Medicine Institute · San Diego, California · NCT05471232

• Registry for individuals with Rett syndrome

  This study is gathering information from people with Rett syndrome and their caregivers to help improve care and develop new treatments for the condition.

  Recruiting at 19 sites International Rett Syndrome Foundation · Birmingham, Alabama and 18 other locations · NCT05432349

• Evaluating treatment for patients with intellectual and severe multiple disabilities

  This study looks at how different treatments and care from healthcare professionals can help people with intellectual disabilities and severe multiple disabilities feel better and improve their lives.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT04781452

• Using sensors to help non-verbal individuals communicate their needs

  This study is trying to see if using heart rate and breathing monitors can help non-verbal individuals with intellectual disabilities, autism, or cerebral palsy communicate their needs better.

  Recruiting University of Oslo · Oslo · NCT04199299

• Cognitive remediation program for adults with intellectual disabilities

  This study tests a new program aimed at helping adults with mild to moderate intellectual disabilities improve their attention and social skills to see if it can make a positive difference in their lives.

  Recruiting Hôpital le Vinatier · Lyon, Auvergne-Rhône-Alpes · NCT04025398

• Observational study of genetic variants in neurodevelopmental disorders

  This study looks at how certain genetic changes affect people with neurodevelopmental disorders like autism and intellectual disabilities to better understand their treatment and related health issues.

  Recruiting Columbia University · New York, New York · NCT03492060

NIH-funded research (26)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding genetic causes of intellectual disability across diverse populations

  Aiming to find gene variants that contribute to intellectual disability in people from African, Asian, and European backgrounds to improve diagnosis and future treatments.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11397280

• Understanding early cognitive skills in children with Down syndrome

  We’re studying how early thinking skills develop in young children with Down syndrome and what factors influence severe intellectual disability later on.

  NIH research Colorado State University · Fort Collins, United States · NIH-11396397

• Including Adults with Intellectual Disability in Precision Medicine

  This grant funds a study to help adults with intellectual disability participate more fully in precision medicine research and understand how to respect their consent and privacy while sharing useful health information.

  NIH research Syracuse University · Syracuse, United States · NIH-11376567

• Step It Up+: helping adults with intellectual disability be more active

  This 16-week program helps adults with intellectual disability use goal-setting, a web dashboard, and a support coach to increase daily steps and aerobic and strength activity.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11308675

• Understanding brain responses in children with autism and intellectual disability

  This project uses child-friendly EEG and eye-tracking to measure brain responses and looking patterns in 6–11-year-old children with autism and intellectual disability.

  NIH research Yale University · New Haven, United States · NIH-11269157

• Understanding and fixing SETD5-related brain problems in children with autism and intellectual disability

  Developing treatments that target the SETD5 gene to help young children with autism and intellectual disability.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11266125

• Including adults with intellectual disability in precision medicine

  This project creates a tailored consent toolkit to help adults with intellectual disability understand and take part in precision medicine studies.

  NIH research Syracuse University · Syracuse, United States · NIH-11264320

• How a small sugar tag on proteins (O-GlcNAc) affects X-linked intellectual disability

  The team is looking at whether mutations in the OGT gene change a protein 'sugar tag' called O-GlcNAc and how those changes harm brain cells in people with X-linked intellectual disability.

  NIH research University of Georgia · Athens, United States · NIH-11262835

• Understanding how mutations in a specific gene affect intellectual disability

  This study is looking at how changes in the KDM5C gene might lead to intellectual disabilities by exploring how these changes affect brain development, and it's designed for anyone interested in understanding more about the causes of these conditions and potential future treatments.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11184423

• Do unclear changes in the ANKRD17 gene cause neurodevelopmental problems?

  This project checks whether unclear (uncertain) changes in the ANKRD17 gene lead to neurodevelopmental disability so families and doctors can better understand genetic test results.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11182583

• Why some children with Down syndrome have very low early thinking skills

  Researchers will follow a group of young children with Down syndrome over three years to learn which medical, behavior, and blood markers link to very low early cognitive skills.

  NIH research Colorado State University · Fort Collins, United States · NIH-11181508

• Finding genes linked to intellectual disability in families from Africa, Asia, and Europe

  This project looks for genetic changes that may cause intellectual disability by sequencing DNA from affected adults and their family members from African, Asian, and European backgrounds.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11164594

• Helping Adults with Intellectual Disability Participate in Personalized Medicine

  This initiative helps adults with intellectual disability join personalized medicine efforts, ensuring their voices are heard and their health needs are met.

  NIH research Syracuse University · Syracuse, United States · NIH-11143784

• Tracking brain activity and movement in children with intellectual disabilities

  This study is testing a new, safe way to watch how children's brains work while they move and learn, which could help doctors better understand and treat kids with intellectual disabilities.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11134735

• Investigating how the p53 protein affects learning and memory in the brain.

  This study is looking at how a protein called p53 in a part of the brain important for learning and memory affects memory formation, and it aims to help us understand how problems with this protein might lead to intellectual disabilities.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11077881

• Understanding how neuron dysfunction affects learning and seizures in children

  This study is looking at how a gene called CASK might cause intellectual disabilities and seizures in kids, using mice to learn more about how problems in certain brain cells can affect thinking and lead to seizures, with the hope of finding better treatments for children who need help.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11061199

• Understanding how a specific protein modification affects intellectual disability in males

  This study is looking at how changes in a specific protein related to X-linked intellectual disability (which affects some boys) might help us find new ways to treat this condition.

  NIH research University of Georgia · Athens, United States · NIH-11034104

• Including individuals with intellectual disabilities in autism research

  This study is looking at how children with autism and intellectual disabilities think and pay attention, using cool tools like brain scans and eye trackers, to help us find better ways to support them.

  NIH research Yale University · New Haven, United States · NIH-11024110

• Increasing physical activity in adults with intellectual disabilities

  This study is testing a fun 16-week program called Step It Up+ to help adults with intellectual disabilities get more active through personalized workouts and support from coaches, making it easier for them to enjoy exercise and connect with others.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11013331

• Understanding and reversing brain dysfunction linked to autism and intellectual disability

  This study is looking into how certain genes might affect young children with autism and intellectual disabilities, especially those diagnosed early, to find new ways to help improve their social and communication skills.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11010745

• Understanding how certain genetic variants affect a key enzyme linked to intellectual disability in males

  This study is looking at how certain changes in a gene related to a brain enzyme might affect people with X-Linked Intellectual Disability (XLID), helping us learn more about the condition and possibly leading to new treatments for those affected.

  NIH research University of Georgia · Athens, United States · NIH-11002292

• Understanding how individuals with profound intellectual disability respond and communicate

  This study is working on new ways to understand how people with profound intellectual disabilities think and respond, so we can better support their needs and make sure their voices are heard.

  NIH research Hugo W. Moser Res Inst Kennedy Krieger · Baltimore, United States · NIH-10948744

• Understanding the genetic causes of intellectual disability in diverse families

  This study is looking at the genes of families from different backgrounds to find out what might cause intellectual disability, hoping to help improve diagnosis and treatment for those affected.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10906931

• Including adults with intellectual disabilities in personalized medicine efforts

  This study is all about helping adults with intellectual disabilities take part in personalized healthcare research, making sure their unique needs are understood and that they feel included and empowered in the process.

  NIH research Syracuse University · Syracuse, United States · NIH-10894293

• Evaluating uncertain genetic variants linked to intellectual disabilities

  This study is looking at certain genetic changes in the ANKRD17 gene that might be linked to brain development issues, and it aims to find out if these changes are harmful or not, which could help families and doctors better understand and manage related conditions.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10789572

• Understanding cognitive development in children with Down syndrome

  This study is looking at how children with Down syndrome, especially those with more severe intellectual challenges, grow and learn over time, and it aims to find out what helps or hinders their cognitive development, so we can better understand their unique abilities.

  NIH research Colorado State University · Fort Collins, United States · NIH-10780464

Related topics

Quick answers

How many Intellectual Disability clinical trials are recruiting right now?

23, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (10 trials), Norway (2 trials), Germany (2 trials), Sweden (2 trials), Taiwan (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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