Identifying genetic causes of heart issues in epilepsy patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the genetic factors that may contribute to sudden unexpected death in patients with epilepsy. It focuses on individuals aged 18 to 50 who are at high risk for sudden death due to their epilepsy or related conditions. Participants will be assessed using a risk scoring tool and may include blood relatives of patients with a history of epilepsy or cardiac issues. Genetic testing will be conducted using blood samples or buccal cells to identify potential underlying cardiovascular disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ages 18 - 50 with a diagnosis of epilepsy or seizures, or syncope or drowning or cardiac arrest or sudden death or an abnormal ECG suggestive of an arrhythmia
* Blood-relatives (Aged 18+) of a patient with a history of epilepsy, seizure, cardiac arrest, sudden death, drowning, syncope or arrhythmia

Exclusion Criteria:

* Those who are unable to provide written consent.
* Prisoners (vulnerable population)
* Seizures secondary to ischemic events
* Traumatic brain injury resulting in seizures
* History of cranial surgery
* History of brain tumor

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Virend K. Somers, MD PhD — Mayo Clinic
• Study coordinator: Somers CPL Lab
• Email: CPL@mayo.edu

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.