Understanding how seizures affect breathing and consciousness
Inhibition of central CO2 chemoreception by seizures: Effects on ventilation, cardiovascular control and postictal recovery of consciousness
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11079660
This study is looking into why some people with epilepsy experience sudden unexpected death, focusing on how seizures might affect breathing and heart function, and it aims to find new ways to help those at higher risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11079660 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind sudden unexpected death in epilepsy (SUDEP), focusing on how seizures can lead to respiratory arrest and autonomic dysfunction. By studying the role of serotonin neurons in regulating breathing and arousal, the research aims to uncover why some seizures result in severe outcomes while others do not. The approach includes measuring the hypercapnic ventilatory response in patients to assess their risk. Ultimately, the goal is to develop new treatments and identify biomarkers for patients at higher risk of SUDEP.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with refractory epilepsy who have experienced generalized tonic-clonic seizures.
Not a fit: Patients with well-controlled epilepsy or those who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent SUDEP and improve the safety of patients with epilepsy.
How similar studies have performed: While the specific mechanisms of SUDEP are still being explored, related research has shown promise in understanding seizure impacts on respiratory function and autonomic control.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RICHERSON, GEORGE B — UNIVERSITY OF IOWA
- Study coordinator: RICHERSON, GEORGE B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.