Condition

Alzheimer Dementia (AD) clinical trials and research

• 20Clinical trials
• 1New in 30 days
• 10Countries

Newest Alzheimer Dementia (AD) clinical trials

All recruiting trials (20)

• Aging Brain Health Initiative in Fujian

  This observational study will follow about 3,000 older adults in Fujian to see how Alzheimer's-related changes develop and to test new digital tests, biomarkers, and imaging tools for early diagnosis.

  Recruiting at 4 sites Fujian Medical University Union Hospital · Fushun, Fujian and 3 other locations · NCT07891429

• Restoring Cervical Lymphatic Drainage in Alzheimer’s Disease

  A small study tests whether a minimally invasive surgery to improve cervical lymphatic drainage can affect biomarkers, brain imaging, and cognition in people with Alzheimer's who can’t access other disease-modifying therapies.

  Recruiting University of Siena · Siena, Tuscany · NCT07854327

• Home-based gamma-tACS with personalized cognitive training for mild Alzheimer's disease

  This study tests a home-delivered combination of gamma-frequency tACS and individualized memory training to see if it helps people with mild Alzheimer's disease.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia, Brescia and 1 other locations · NCT07839650

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Low-Dose Radiation Therapy to See if It Helps Alzheimer's and Inflammatory Dementias

  Researchers will test whether giving small amounts of whole-brain radiation over a short course, then monthly boosts for a year, is tolerable and safe in people over 50 with Alzheimer's or dementia with inflammatory features.

  Recruiting Phase 1/2 Renaissance Institute of Precision Oncology and Radiosurgery · Winter Park, Florida · NCT07693140

• Risk-score predictor for dementia in older adults with depression

  This study tests whether a point-based risk score from electronic medical records can accurately predict which older adults with depression will develop dementia.

  Recruiting Second Affiliated Hospital of Nanchang University · Nanchang, Jiangxi · NCT07676851

• IL-2 plus semaglutide in Alzheimer's disease

  This study tests a combination of IL-2 and semaglutide to see if it can help people with Alzheimer's disease.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT07651319

• BCI with 40Hz Stimulation for Alzheimer’s Disease

  This study tests whether a non-invasive brain-computer interface with 40Hz audio-visual stimulation can improve thinking skills in people with Alzheimer’s disease.

  Recruiting at 2 sites Ruijin Hospital · Shanghai, Shanghai Municipality and 1 other locations · NCT07618481

• Lecanemab in Early to Moderate Alzheimer's Disease using Multi-omics data

  This study tests whether Lecanemab can help people with early-to-moderate Alzheimer's disease and uses multiple biological data types to understand its effects.

  Recruiting Phase 4 First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT07604896

• Predicting pre-dementia progression in APOE‑ε4 carriers

  This project will try a combined genetic, blood, and wearable-monitoring model to see if it can predict which cognitively normal or very mildly impaired adults aged 55+ with an APOE‑ε4 gene will develop biomarker-confirmed MCI within 24 months.

  Recruiting Prevention Research Consortium Corp. · San Diego, California · NCT07516119

• Ultra-high-resolution PET imaging of aging, neurodegeneration, and psychotic disorders

  We will test whether ultra-high-resolution PET and 3T MRI scans can reveal early brain and spinal cord changes in healthy adults and people with Alzheimer's, Parkinson's disease, ALS, PSP, REM sleep behavior disorder, or psychotic disorders.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT07509125

• Brain blood flow and sugar transport in Alzheimer's with and without type 2 diabetes

  This project will try to see if patterns of brain blood flow and sugar use differ between people with Alzheimer's disease who do and do not have type 2 diabetes and compared with healthy older adults.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Herlev · NCT07482072

• Online positive psychology program to support thinking and brain health in early memory changes

  This study will test whether an online positive psychology program can improve thinking, brain function, and wellbeing in older adults with early memory problems (Subjective Cognitive Decline or Mild Cognitive Impairment).

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07289061

• Brain stimulation plus methylphenidate for apathy in Alzheimer's

  This trial will test whether combining short sessions of noninvasive brain stimulation (intermittent theta burst) with methylphenidate can reduce apathy in people with Alzheimer's disease or mixed Alzheimer's/vascular dementia.

  Recruiting Phase 2 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07279740

• Levetiracetam to prevent seizures in adults with Down syndrome and Alzheimer's disease

  This trial will test whether the anti-seizure medicine levetiracetam can prevent tonic-clonic seizures and slow cognitive decline in adults over 40 who have Down syndrome and symptomatic Alzheimer's disease.

  Recruiting Phase 3 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Granada, Andalusia and 4 other locations · NCT07234695

• Intermittent deep brain stimulation of the nucleus basalis to treat Alzheimer's

  This will test whether intermittent deep brain stimulation of a small brain region called the nucleus basalis can help sustain or improve thinking and memory in people aged 65–85 with early-stage Alzheimer's disease.

  Recruiting Phase 1 Augusta University · Augusta, Georgia · NCT07218081

• Transcranial pulse stimulation to help people with early Alzheimer's disease

  We will test whether non-invasive transcranial pulse stimulation can improve thinking, memory, and behavior in people aged 60–90 with early Alzheimer's disease.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT07143734

• Investigating genetic factors in patients with neurodegenerative dementia

  This study is trying to find out if certain genetic factors are linked to neurodegenerative dementias like Alzheimer's and Lewy Body dementia by looking at blood samples from patients and their family members.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05911932

• Using brain stimulation to improve cognitive control in older adults with mild cognitive impairment

  This study is testing if a new type of brain stimulation can help older adults with mild cognitive impairment improve their thinking skills while they play a video game.

  Recruiting University of Texas at Austin · Austin, Texas · NCT05907343

• Genetic factors in early-onset dementia

  This study is trying to find out how genetics might affect the risk and progression of early-onset dementia by looking at people with dementia, their families, and healthy individuals.

  Recruiting Columbia University · New York, New York · NCT04906863

Related topics

Quick answers

How many Alzheimer Dementia (AD) clinical trials are recruiting right now?

20, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (6 trials), China (4 trials), Italy (2 trials), Canada (2 trials), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1/2: 2, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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