Condition

Status Epilepticus clinical trials and research

• 18Clinical trials
• 30NIH research projects
• 12Countries

Newest Status Epilepticus clinical trials

All recruiting trials (18)

• Recovery after coma from serious brain injury or illness

  This observational study will follow adults who are unconscious due to a serious brain illness or injury to see what medical, neurological, psychological, and social factors are linked with recovery over time.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07614074

• Augmented kidney clearance in neurocritical care

  This project will test whether adults in the neuro-ICU with severe brain injury, stroke, seizures, or brain infections have faster kidney clearance (ARC) that can lower antiseizure and antibiotic drug levels.

  Recruiting at 3 sites University of Alberta · Lexington, Kentucky and 2 other locations · NCT07410624

• Ketamine added to levetiracetam to stop prolonged convulsive seizures

  This trial will test whether giving ketamine (two different doses) along with levetiracetam helps stop benzodiazepine-refractory status epilepticus in people age 1 and older.

  Recruiting at 36 sites Phase 3 University of Virginia · Birmingham, Alabama and 62 other locations · NCT06907173

• Improving prognosis for patients with Status Epilepticus

  This study is trying to find blood markers that can help predict how well patients with Status Epilepticus will recover in the ICU and how their thinking skills may change after they leave the hospital.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06590883

• Using Rapid-Response EEG to Diagnose Seizures in Children

  This study is testing if a new quick EEG device can help doctors diagnose seizures in children faster than the standard method.

  Recruiting Children's Hospital at Montefiore · The Bronx, New York · NCT06564662

• Two-way video support for paramedics caring for infants with life-threatening breathing problems.

  This project will test whether a two-way video link with pediatric emergency doctors helps paramedics give better care to infants with life-threatening breathing problems during transport.

  Recruiting at 4 sites Boston Medical Center · Los Angeles, California and 8 other locations · NCT06441760

• Using perampanel to prevent seizures after cardiac arrest

  This study is testing if the medication perampanel can help prevent seizures in patients who have survived a cardiac arrest and are in a coma.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06401707

• Improving treatment times for children with status epilepticus

  This study is testing a new way to speed up treatment for children with status epilepticus in hospitals to see if it helps them get their first dose of medicine faster.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT06194747

• Understanding patient experiences after severe seizures

  This study looks at the long-term experiences and challenges faced by people who have survived severe seizures to see how it affects their daily lives and well-being.

  Recruiting at 15 sites Versailles Hospital · Angoulême and 18 other locations · NCT06100978

• Investigating imaging techniques for diagnosing non-convulsive status epilepticus

  This study is testing three different imaging techniques to see which one best helps doctors diagnose non-convulsive status epilepticus in patients.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06017973

• Using EEG to guide anesthesia for seizures after cardiac arrest

  This study is testing two different ways of using EEG to guide anesthesia in patients who have had a cardiac arrest and are experiencing severe seizures, to see which method works better at controlling those seizures.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05851391

• Registry for patients treated for Status Epilepticus

  This study is trying to gather information about adults with Status Epilepticus to see how different treatments and their outcomes vary across various hospitals in Europe.

  Recruiting at 2 sites Erasme University Hospital · Linz and 10 other locations · NCT05839418

• Using exogenous ketone esters to treat refractory status epilepticus in children

  This study is testing if giving kids with severe seizures a special drink can help control their seizures when regular medications aren't working.

  Recruiting Phase 2/3 Sohag University · Sohag · NCT05674552

• Creation of a database linking EEG recordings with clinical information for epilepsy patients

  This study is creating a database that links brain wave recordings and medical information from epilepsy patients to see if it can help improve treatment and predict seizures better.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT05140265

• Understanding the causes of severe epilepsy and autoimmune encephalitis

  This study is trying to understand what causes severe epilepsy and related brain inflammation by looking at samples from patients to find new ways to treat these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04421846

• Understanding recovery after brain hemorrhage

  This study looks at how different types of brain bleeding affect recovery and how treatments in the hospital can impact patient outcomes for people with serious brain injuries.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT04189471

• Monitoring brain activity in patients with severe seizures

  This study is testing if continuous brain monitoring can help improve recovery and outcomes for patients with severe seizures in the ICU compared to standard care.

  Recruiting Barts & The London NHS Trust · London · NCT04170491

• Registry for patients with Status Epilepticus in critical care

  This study is trying to gather information about patients with Status Epilepticus in critical care to see how they are treated and what outcomes they have.

  Recruiting at 20 sites Ictal Group · Angoulême and 19 other locations · NCT03457831

NIH-funded research (30)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Microglia Help Finish Seizures and Heal the Brain

  Scientists are studying how brain immune cells (microglia) help end severe seizures and repair brain damage, with potential new ideas for people who have had status epilepticus.

  NIH research University of Virginia · Charlottesville, United States · NIH-11607998

• ARISEN Network pilot funding to advance autoimmune encephalitis and NORSE care

  A pilot grants program within the ARISEN network offers small funding to researchers to speed up clinical trials and improve management and treatment of autoimmune encephalitis, Rasmussen syndrome, and NORSE.

  NIH research Emory University · Atlanta, United States · NIH-11417482

• ARISEN Network: Better Diagnosis and Treatment for Autoimmune Brain Inflammation in Children

  A large team at Emory is building ways to diagnose autoimmune brain inflammation in kids earlier and tailor treatments to improve outcomes.

  NIH research Emory University · Atlanta, United States · NIH-11417476

• ARISEN Network: Patient-centered outcomes in autoimmune brain inflammation and status epilepticus

  A nationwide registry study from Emory will collect patient- and caregiver-reported outcomes to understand how neuroinflammatory brain diseases affect people and what helps them most.

  NIH research Emory University · Atlanta, United States · NIH-11417471

• ARISEN: A regional network to understand autoimmune brain diseases in kids

  A national, multi-center effort follows children with autoimmune brain diseases to better understand how their condition progresses and how it affects thinking and everyday life.

  NIH research Emory University · Atlanta, United States · NIH-11417467

• ARISEN: Advancing research on autoimmune brain diseases and neuroinflammation

  This grant supports a Career Enhancement Core to train the next generation of clinician-scientists studying autoimmune brain diseases like autoimmune encephalitis, Rasmussen’s syndrome, and NORSE, with a focus on pediatric cases.

  NIH research Emory University · Atlanta, United States · NIH-11417463

• ARISEN aims to improve outcomes for autoimmune brain diseases in children and adults

  A network-led effort to better understand and treat autoimmune brain conditions like autoimmune encephalitis, Rasmussen syndrome, and NORSE through a multi-center registry and coordinated care approaches.

  NIH research Emory University · Atlanta, United States · NIH-11417457

• ARISEN Network: Understanding and Improving Rare Autoimmune Brain Disorders in Children and Adults

  A national, multi-center effort is collecting data on sudden immune-related brain diseases like autoimmune encephalitis, NORSE, and Rasmussen syndrome to learn how these conditions progress and how best to treat them.

  NIH research Emory University · Atlanta, United States · NIH-11417431

• New treatments to stop seizures from organophosphate (pesticide/nerve agent) poisoning using zebrafish

  Researchers are using tiny zebrafish to search for medicines that could stop seizures after exposure to organophosphate pesticides or nerve agents for people who suffer that kind of poisoning.

  NIH research Northwestern University · Chicago, United States · NIH-11405055

• Verapamil as a neuroprotective and anti-inflammatory aid after organophosphate-induced brain injury

  A study to see if verapamil can protect the brain and reduce inflammation after dangerous organophosphate exposure that can cause lasting brain problems.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11401833

• Quality improvements to speed up treatment for pediatric status epilepticus

  A national study tests a set of quick, standardized steps to treat pediatric seizures faster and reduce brain injury.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11393365

• Novel hydrophilic neurosteroids to stop benzodiazepine-resistant seizures after nerve agent exposure

  This grant aims to develop water-friendly neurosteroids that could prevent ongoing seizures and brain damage after nerve agent exposure, helping people who suffer organophosphate poisoning.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11391364

• Transcranial stimulation to help adults with focal status epilepticus

  A small clinical trial will test whether non-invasive brain stimulation can safely help adults with hard-to-treat focal seizures in hospital settings.

  NIH research Stanford University · Stanford, United States · NIH-11299952

• Ketamine Add-On for Established Status Epilepticus Treatment

  A big government-funded study will test if adding ketamine to standard seizure treatment helps more patients recover from a dangerous brain emergency.

  NIH research University of Virginia · Charlottesville, United States · NIH-11262172

• Preventing epilepsy after a severe prolonged seizure by calming brain inflammation

  Seeing whether calming inflammation right after a severe prolonged seizure can lower the chance of developing long-term epilepsy in adults.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11237179

• Faster treatment for status epilepticus in children

  Hospitals will use a standard set of care changes to help children (infants through 11 years) get faster treatment for prolonged seizures to lower the chance of brain injury and complications.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11195136

• Verapamil to protect the brain after organophosphate-caused seizures

  Researchers are giving the blood-pressure drug verapamil after severe seizures caused by organophosphate poisoning to try to reduce brain inflammation and long-term problems with memory and seizures.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11190447

• ARISEN: Network for immune-related brain inflammation and severe seizures

  This project is building a national network and registry to gather health information from children and adults with immune-related brain inflammation and severe seizure conditions to help speed diagnosis and improve care.

  NIH research Emory University · Atlanta, United States · NIH-11173107

• Understanding Brain Inflammation in Prolonged Childhood Seizures

  This project explores how brain inflammation contributes to prolonged seizures in children, aiming to find new ways to help those at risk of developing epilepsy.

  NIH research University of Virginia · Charlottesville, United States · NIH-11084538

• Improving the identification and classification of status epilepticus using advanced data analysis.

  This study is looking at a serious condition called status epilepticus to find better ways to identify and treat patients who are at risk, using advanced technology to analyze health records and improve our understanding of this condition.

  NIH research University of Chicago · Chicago, United States · NIH-11041059

• Investigating the causes and outcomes of childhood status epilepticus in Africa

  This study is looking at how to better understand and treat children in Nigeria who experience a serious condition called status epilepticus, with the goal of finding ways to help them recover and improve their long-term health.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11003575

• Monocytes in the brain may worsen the effects of severe seizures

  This study is looking at how certain immune cells called monocytes enter the brain during and after severe seizures, and how they might contribute to inflammation and memory problems; by finding ways to stop these cells from getting in, researchers hope to help people who experience these seizures and prevent future is

  NIH research Emory University · Atlanta, United States · NIH-11001911

• Improving emergency treatment for prolonged seizures

  This study looks at how emergency medical teams treat prolonged seizures, called status epilepticus, and aims to find out why they sometimes don't use important medications, like benzodiazepines, so they can improve care for patients having these serious seizures.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11001643

• Understanding how inflammation affects epilepsy after severe seizures

  This study is looking at how inflammation after long seizures might lead to epilepsy, and it aims to find new ways to help people who have had these serious seizures avoid developing epilepsy in the future.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10997442

• Using ketamine to improve treatment for severe seizures

  This study is looking at whether adding ketamine to the usual treatment of levetiracetam can help people with severe seizures called status epilepticus when their current treatments aren't working.

  NIH research University of Virginia · Charlottesville, United States · NIH-10983488

• Using intravenous topiramate to treat severe seizures that don't respond to other medications.

  This study is looking at how well intravenous topiramate can help people with severe seizures that don’t respond to regular treatments, hoping to offer a better option for those in need.

  NIH research Prevep, INC. · Bethesda, United States · NIH-10932890

• Improving the speed of treatment for prolonged seizures in children

  This study is working to make sure that children with prolonged seizures get the right treatment faster by using a set of helpful steps in hospitals, so they can recover better and stay safe.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10932198

• Using verapamil to protect the brain and reduce inflammation after organophosphate poisoning

  This study is looking at whether verapamil, a heart medication, can help protect the brain and reduce inflammation in people who have had seizures caused by exposure to certain toxic chemicals, with the hope of improving long-term brain health and reducing problems like memory issues and more seizures.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10915000

• Investigating the causes and outcomes of childhood status epilepticus in Nigeria

  This study is looking at how to better understand and help children in sub-Saharan Africa who have a serious seizure condition called status epilepticus, especially those who experience it as their first seizure, by finding out what factors might affect their recovery and development.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10833085

• Improving emergency treatment for prolonged seizures

  This study looks at how emergency medical teams treat people having severe seizures and aims to understand why they sometimes don't use important medications, so they can improve care for patients in these situations.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10808042

Related topics

Quick answers

How many Status Epilepticus clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (10 trials), France (3 trials), Belgium (2 trials), Canada (2 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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