Understanding how brain circuits control seizures in epilepsy
Neural circuit mechanisms controlling seizures
This study is looking at how certain brain cells behave during seizures in people with temporal lobe epilepsy, with the hope of finding new ways to help those who struggle to control their seizures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11164717 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind temporal lobe epilepsy (TLE), the most common form of epilepsy in adults, which often leads to uncontrolled seizures and cognitive decline. By utilizing advanced techniques that combine light and calcium imaging, the study aims to identify specific brain cells that are active during seizures. The researchers will use two different animal models of TLE to explore how these cells contribute to seizure activity and whether targeting them can help control seizures. This approach could lead to the development of more effective therapies for patients who do not respond to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with temporal lobe epilepsy who experience uncontrolled seizures despite current treatment options.
Not a fit: Patients with epilepsy types other than temporal lobe epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better control seizures in patients with temporal lobe epilepsy.
How similar studies have performed: Other research has shown promise in using optogenetic techniques to control seizure activity, suggesting that this approach may lead to significant advancements in epilepsy treatment.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Nguyen, Quynh Anh — Vanderbilt University
- Study coordinator: Nguyen, Quynh Anh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.