Managing seizures in critically ill children using EEG monitoring
Official title: Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
Run by Children's Hospital of Philadelphia · NCT03419260 · Data updated 2026-11-12
This study looks at how continuous EEG monitoring can help doctors manage seizures in critically ill children and improve their care in the hospital.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Month to 18 Years |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | Children's Hospital of Philadelphia Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Status | Recruiting |
| Started | March 13, 2017 |
| Main results expected | January 1, 2028 |
| Study ends | January 1, 2028 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT03419260 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are critically ill children aged 1 month to 18 years who require clinically indicated continuous EEG monitoring.
✕Probably not a fit
Patients who are expected to have their technological support discontinued within two days or those admitted for intracranial EEG monitoring may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on critically ill children who require continuous EEG monitoring to identify and manage electrographic seizures. The study aims to track these patients to identify risk factors for seizures and develop prediction models to optimize EEG resource allocation. Additionally, it evaluates the safety of current seizure management strategies guided by a standardized EEG monitoring pathway at the Children's Hospital of Philadelphia. By analyzing data from these patients, the study seeks to improve seizure management in pediatric intensive care settings.
Why it matters
Potential benefit: If successful, this study could enhance the identification and management of seizures in critically ill children, leading to better patient outcomes.
How similar studies have gone: While there is limited data on optimal seizure management strategies, similar studies have shown promise in using EEG monitoring for seizure identification in critically ill patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Care in the Children's Hospital of Philadelphia Pediatric ICU. 2. Clinically indicated continuous EEG monitoring. 3. Age \> 1 month to 18 years. Exclusion Criteria: 1. Admitted for Phase 2 (intracranial) EEG monitoring. 2. Intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.
Where it's running
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Nicholas S Abend, MD — Children's Hospital of Philadelphia
- Study coordinator: Nicholas S Abend, MD
- Email: abend@chop.edu
- Phone: 215-590-1719
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.