Study of early life factors affecting maternal and child health
Official title: Early Life Origins of Pediatric and Adult Diseases: Boston Birth Cohort Study
Run by Johns Hopkins Bloomberg School of Public Health · NCT03228875 · Data updated 2026-11-12
This study looks at how factors from early life affect the health of mothers and their children, focusing on women giving birth at Boston Medical Center.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 50 Years |
| Sex | All |
| Enrollment | 24000 (estimated) |
| Sponsor | Johns Hopkins Bloomberg School of Public Health Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | October 1998 |
| Main results expected | December 2028 |
| Study ends | December 2032 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT03228875 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include mothers delivering singleton live infants at Boston Medical Center, particularly those with preterm births or low birth weight infants.
✕Probably not a fit
Patients who have pregnancies resulting from in vitro fertilization, multiple gestations, or significant fetal abnormalities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The Boston Birth Cohort Study investigates how early life exposures influence health outcomes for mothers and their children. It enrolls women delivering singleton live infants at Boston Medical Center, focusing on those with either preterm births or full-term births with low birth weight. The study collects high-quality biospecimens and comprehensive data on environmental exposures, clinical history, and maternal health through standardized interviews and medical record reviews. Follow-up assessments are conducted from birth until the child reaches 21 years of age.
Why it matters
Potential benefit: If successful, this study could provide insights into preventing adverse health outcomes related to early life exposures.
How similar studies have gone: Other studies have shown success in understanding the impact of early life factors on health, making this approach both relevant and valuable.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mothers who deliver singleton live births at Boston Medical Center are eligible for the study. Exclusion Criteria: * pregnancies that are a result of in vitro fertilization or that involve multiple gestations, fetal chromosomal abnormalities or major birth defects.
Where it's running
-
Boston Medical Center
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Xiaobin Wang, MD, ScD — Johns Hopkins Bloomberg School of Public Health
- Study coordinator: Xiaobin Wang, MD, ScD
- Email: xwang82@jhu.edu
- Phone: 410-9555824
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.