Autophagy and cell-death balance in placenta-related pregnancy complications
Official title: Study of the Autophagy/Apoptosis Balance in Placental Vascular Pathologies
Run by Centre Hospitalier Universitaire de Nīmes · NCT06779916 · Data updated 2026-11-12
This observational project will test whether changes in autophagy and apoptosis in the placenta are linked to pre-eclampsia or intrauterine growth restriction in pregnant women delivering at Nîmes University Hospital.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nīmes Academic / other |
| Locations | 1 site (Nîmes) |
| Status | Recruiting |
| Started | May 2, 2025 |
| Main results expected | May 1, 2028 |
| Study ends | May 1, 2029 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT06779916 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnant women hospitalized at and delivering in Nîmes University Hospital who develop pre-eclampsia and/or intrauterine growth restriction, can give informed consent, and have health insurance are ideal candidates.
✕Probably not a fit
Women with multiple pregnancies, preexisting hypertension or proteinuria before pregnancy, those unable to consent, or those enrolled in interventional drug studies are excluded and would not benefit from participation in this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study of pregnant women who develop placental vascular complications such as pre-eclampsia or fetal growth restriction and deliver at Nîmes University Hospital. The team will collect blood and urine specimens (and correlate with clinical data at delivery) to measure markers related to autophagy and apoptosis in trophoblasts. The study seeks patterns in the autophagy–apoptosis balance that distinguish affected pregnancies and relate to maternal-fetal outcomes. Findings aim to identify candidate molecular markers that could inform future screening or preventive strategies.
Why it matters
Potential benefit: If successful, the study could identify new markers that help detect women at higher risk of placenta-mediated complications and guide earlier monitoring or targeted prevention.
How similar studies have gone: Previous observational work, including the GrossAuTop-1 project, documented variability in autophagy and apoptosis during pregnancy but direct links to placental vascular complications remain preliminary and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women developing a placental vascular complication (preeclampsia and/or intrauterine growth retardation), hospitalized and delivering at Nimes University Hospital. * Pregnant woman with free and informed consent. * Pregnant woman affiliated with and/or benefiting from a health insurance scheme. Exclusion criteria: * Multiple pregnancy. * Presence of hypertension and/or proteinuria prior to pregnancy. * Participant in an interventional drug study. * Persons in a period of exclusion determined by another study. * Persons under court protection, guardianship or curatorship. * Persons unable to give consent. * Persons for whom it is impossible to give informed information.
Where it's running
-
Nimes University Hospital
Nîmes, France Recruiting
Study contacts
- Principal investigator: Marie PORTES, Dr. — Centre Hospitalier Universitaire de Nīmes
- Study coordinator: Sylvie BOUVIER, Dr.
- Email: sylvie.bouvier@chu-nimes.fr
- Phone: +334.66.68.32.11
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.