Exploring the impact of maternal microbiota on child health
Official title: Human Genes and Microbiota in Early Life (HuGME)
Run by Guangzhou Women and Children's Medical Center · NCT06926166 · Data updated 2026-11-12
This study looks at how the bacteria in pregnant women's bodies affect their babies' health and development to see if it can help prevent future health issues.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 20000 (estimated) |
| Sponsor | Guangzhou Women and Children's Medical Center Academic / other |
| Locations | 1 site (Guangzhou) |
| Status | Recruiting |
| Started | April 1, 2019 |
| Main results expected | December 31, 2038 |
| Study ends | December 31, 2038 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT06926166 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include pregnant women under 20 weeks of gestation who plan to deliver at the Guangzhou Women and Children's Medical Center.
✕Probably not a fit
Patients who are not pregnant or those who refuse to provide blood and stool samples will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the effects of maternal microbiota during pregnancy and the early colonization of infants' microbiota on long-term health outcomes. It focuses on the interactions between maternal and infant gut microbiomes, host genetics, and environmental factors, aiming to understand their roles in the development of conditions such as obesity, allergic diseases, and neurodevelopmental disorders. The study will collect blood and stool samples from pregnant women and their infants to analyze these interactions and their implications for health. The findings could lead to new strategies for predicting and preventing diseases in later life.
Why it matters
Potential benefit: If successful, this study could provide insights into preventing long-term health issues in children by understanding the role of maternal microbiota.
How similar studies have gone: While the microbiome's role in health has been studied, this specific approach focusing on maternal-offspring interactions is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Pregnant women with \< 20 weeks of gestation Pregnant women intended to eventually deliver in Guangzhou Women and Children's medical center Permanent residengts of families intended to remain in Guangzhou with their child for ≥3 years Exclusion Criteria: Refuses to have blood and stool samples stored at Born in Guangzhou cohort study Biobank.
Where it's running
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Guangzhou Women and Children's Medical Center, China
Guangzhou, China Recruiting
Study contacts
- Principal investigator: Xiu Qiu, PhD — Study Principal Investigator Guangzhou Women and Children's Medical Center, China
- Study coordinator: Xiu Qiu,, PhD
- Email: qxiu0161@163.com
- Phone: 0086 20 38367160
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.